HitPredict

Interactor 1: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 359
+	Hs
		1148484 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Hs
		899930 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Dm
		114751 P92031_DROME (24-153): 1.22e-45: 157: 34.09		M9PD53_DROME (21-265): 2.59e-52: 183: 33.74
+	Dm
		1368258 Q9VJ37_DROME (24-153): 1.03e-45: 158: 34.09		Q9VJ00_DROME (21-265): 3.35e-52: 182: 33.74
+	Hs
		903736 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Hs
		839800 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Hs
		903764 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Hs
		1251421 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Hs
		638556 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		RBTN1_HUMAN (27-143): 3.27e-26: 103: 40.83
+	Dm
		112552 Q9VJ37_DROME (24-153): 1.03e-45: 158: 34.09		M9NCY1_DROME (1-83): 1.31e-15: 79.3: 26.19
+	Ce
		104772 LIM7_CAEEL (14-147): 4.14e-45: 155: 33.82		HM14_CAEEL (7-90): 1.7e-13: 72.7: 18.61
+	Mm
		864805 ISL2_MOUSE (12-148): 2.2e-41: 143: 32.61		LHX4_MOUSE (1-82): 2.78e-17: 84.3: 22.89
+	Hs
		1281161 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Hs
		1148497 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		LHX6_HUMAN (7-81): 1.54e-11: 66.9: 20.00
+	Hs
		238115 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMX1B_HUMAN (7-83): 1.54e-16: 82: 19.48
+	Ce
		104771 LIM7_CAEEL (14-147): 4.14e-45: 155: 33.82		LIN11_CAEEL (7-82): 1.52e-11: 66.9: 16.88
+	Hs
		1283500 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		822660 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74
+	Dm
		114396 M9PCA3_DROME (9-154): 8.59e-41: 145: 32.65		M9PCA3_DROME (7-80): 1.83e-11: 67.3: 21.33