HitPredict

Interactor 1: MSH2 (P25847)
DNA mismatch repair protein MSH2 (MutS protein homolog 2)
Gene: MSH2

Interactor 2: EXO1 (P39875)
Exodeoxyribonuclease 1 (EC 3.1.-.-) (Exodeoxyribonuclease I) (EXO I) (Exonuclease I) (Protein DHS1)
Gene: EXO1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	9207118, 9111347, 10835383, 9826691, 30061603, 17720936, 17602897
Identification Methods	two hybrid, coimmunoprecipitation, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006298 - mismatch repair GO:0006310 - DNA recombination
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 964 Sc			1 702
+	Sc
		764584 MSH6_YEAST (17-884): 0: 628: 21.63		EXO1_YEAST (1-702): 0: 679: 100.00
+	Hs
		794340 MSH2_HUMAN (3-960): 0: 933: 39.25		EXO1_HUMAN (1-600): 2.94e-113: 363: 27.10
+	Sc
		425543 MSH2_YEAST (1-964): 0: 1022: 100.00		RAD2_YEAST (1-124): 1.5e-28: 124: 20.16
+	Hs
		855582 MSH6_HUMAN (13-913): 0: 758: 21.07		EXO1_HUMAN (1-600): 2.94e-113: 363: 27.10
+	Hs
		764348 MSH6_HUMAN (13-913): 0: 758: 21.07		FEN1_HUMAN (1-395): 2.22e-107: 333: 19.60
+	Hs
		594227 MSH3_HUMAN (17-941): 0: 661: 22.02		EXO1_HUMAN (1-600): 2.94e-113: 363: 27.10