HitPredict

Interactor 1: LYN (P25911)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	16920712
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0045121 - membrane raft
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 512 Mm			1 429
+	Mm
		411925 LCK_MOUSE (1-512): 0: 591: 62.72		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		763390 FYN_MOUSE (1-510): 0: 580: 53.18		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		434038 LYN_HUMAN (1-512): 0: 612: 96.09		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		976830 ITK_MOUSE (2-503): 8.23e-175: 507: 35.55		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		411873 LCK_HUMAN (1-512): 0: 585: 62.33		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		412375 FYN_HUMAN (1-510): 0: 580: 53.37		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		523175 SRC_HUMAN (1-510): 0: 579: 51.87		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		782848 CSK_MOUSE (64-503): 4.71e-174: 499: 38.19		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Rn
		693647 CSK_RAT (64-503): 3.21e-174: 499: 38.41		PHAG1_RAT (1-429): 0: 764: 89.51
+	Hs
		789135 FRK_HUMAN (23-506): 0: 527: 47.80		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		337571 ABL1_HUMAN (31-509): 9.89e-168: 505: 38.01		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		782829 CSK_HUMAN (64-503): 1.65e-174: 500: 38.19		PHAG1_HUMAN (1-429): 0: 705: 78.21