HitPredict

Interactor 1: TNR5 (P25942)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
Gene: CD40

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 10411888, 12220533, 25416956, 20614026, 25910212, 27716849, 32296183, 9990007, 32041822, 33961781, 9020361, 21282461, 16260598, 9718306, 11562359, 21041727, 9168896, 19667091, 12637493, 21071692 and 11 others

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Identification Methods x-ray crystallography, affinity chromatography technology, two hybrid, pull down, fluorescent resonance energy transfer, biochemical, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid and 2 others

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Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0019899 - enzyme binding
GO:0031625 - ubiquitin protein ligase binding
GO:0035631 - CD40 receptor complex
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 277
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024