Protein: RIR1
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)

Gene: RIR1, RRM1
Organism: Homo sapiens
Interactions: 107
UniProt ID: P23921

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 - ATP binding
GO:0005635 - nuclear envelope
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

663386

RIR2
Ribonucleoside-diphosphate reductase subunit M2

10

14

Small-scale

0.976

High

663427

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

5

14

Small-scale

0.923

High

663382

RIR1
Ribonucleoside-diphosphate reductase large subunit

4

9

Small-scale

0.908

High

663436

KAT5
Histone acetyltransferase KAT5

4

1

Small-scale

0.705

High

300109

GLRX3
Glutaredoxin-3

2

1

High-throughput

0.628

High

663428

TRI69
E3 ubiquitin-protein ligase TRIM69

2

0

High-throughput

0.602

High

486964

PARP1
Poly [ADP-ribose] polymerase 1

2

0

High-throughput

0.585

High

663459

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.576

High

663388

BMI1
Polycomb complex protein BMI-1

1

1

Small-scale

0.561

High

240777

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

663401

RS24
Small ribosomal subunit protein eS24

2

0

High-throughput

0.559

High

663420

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

663439

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

663407

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.536

High

663435

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

572778

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.513

High

663385

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

663429

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

663442

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.513

High

663443

RING2
E3 ubiquitin-protein ligase RING2

1

1

Small-scale

0.512

High

663390

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

Small-scale

0.508

High

663397

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

663408

ATM
Serine-protein kinase ATM

1

0

Small-scale

0.479

High

256774

H2B1K
Histone H2B type 1-K

1

3

High-throughput

0.479

High

663387

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

663394

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

663400

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

663405

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

663410

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

663412

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

663444

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

663421

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

156967

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

289928

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

324090

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

411373

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

445741

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

659353

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

663383

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

663384

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

663389

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

663391

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

663392

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

663395

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

663399

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

663402

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

663404

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

663406

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

663411

CUL3
Cullin-3

1

0

High-throughput

0.458

High

663413

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

663414

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

663416

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

663433

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

663434

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

663438

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

663441

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

663445

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

663446

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

Small-scale

0.458

High

663448

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

663451

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

663452

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

663456

TRM7
tRNA

1

0

High-throughput

0.458

High

663457

EPHA6
Ephrin type-A receptor 6

1

0

High-throughput

0.458

High

663458

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

663460

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

663461

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

663464

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

663398

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.457

High

663453

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

663423

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

587939

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

663437

H2B1A
Histone H2B type 1-A

1

2

High-throughput

0.437

High

663450

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

142281

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

374407

RASH
GTPase HRas

1

0

High-throughput

0.426

High

663403

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.426

High

663409

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

663424

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

663425

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

663440

ARL5B
ADP-ribosylation factor-like protein 5B

2

0

High-throughput

0.328

High

663462

TRI33
E3 ubiquitin-protein ligase TRIM33

2

0

High-throughput

0.318

High

663432

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

371184

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

186882

GPR37
Prosaposin receptor GPR37

1

0

High-throughput

0.279

Low

663418

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

663422

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.279

Low

217843

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

276755

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.249

Low

324540

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

379876

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

642626

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

663396

CXA9
Gap junction alpha-9 protein

1

0

High-throughput

0.249

Low

663415

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

663417

UBE3C
Ubiquitin-protein ligase E3C

1

0

Small-scale

0.249

Low

663419

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

663426

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

663430

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

663447

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

High-throughput

0.249

Low

663449

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.249

Low

663454

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

663455

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

663463

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

330046

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

628602

CAP7
Azurocidin

1

0

High-throughput

0.232

Low

663431

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

663393

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025