HitPredict

Interactor 1: TNR5 (P25942)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
Gene: CD40

Interactor 2: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.768

The method score is based on:

Property Details
Experiments 17878343, 7530216, 12220533, 7533327, 24810049, 20614026, 27716849, 26779844, 9990007, 32041822, 7527023, 10984535, 9384571, 7859281, 16260598, 9718306, 11562359, 21041727, 14517219, 9168896 and 8 others

more...
Identification Methods affinity chromatography technology, pull down, two hybrid, unspecified method, x-ray crystallography, biochemical, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0031625 - ubiquitin protein ligase binding
GO:0035631 - CD40 receptor complex
GO:0035666 - TRIF-dependent toll-like receptor signaling pathway
GO:0051607 - defense response to virus
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 277
Hs

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Last updated: 15 Jul 2024