Protein: RIR1
Ribonucleoside-diphosphate reductase large chain 1 (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit 1) (Ribonucleotide reductase large subunit 1)

Gene: RIR1, RNR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 64
UniProt ID: P21524

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

638700

RIR1
Ribonucleoside-diphosphate reductase large chain 1

6

9

Small-scale

0.942

High

488589

RIR2
Ribonucleoside-diphosphate reductase small chain 1

4

14

Small-scale

0.893

High

638701

RIR3
Ribonucleoside-diphosphate reductase large chain 2

4

9

Small-scale

0.890

High

638731

RIR4
Ribonucleoside-diphosphate reductase small chain 2

2

14

Small-scale

0.777

High

638737

SML1
Ribonucleotide reductase inhibitor protein SML1

7

1

Small-scale

0.752

High

578840

HSC82
ATP-dependent molecular chaperone HSC82

3

2

High-throughput

0.633

High

638717

DBP8
ATP-dependent RNA helicase DBP8

2

0

High-throughput

0.602

High

590528

HSP26
Heat shock protein 26

2

2

High-throughput

0.588

High

638728

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

523051

HSP71
Heat shock protein SSA1

2

3

Small-scale

0.576

High

525915

HSP72
Heat shock protein SSA2

2

3

Small-scale

0.576

High

638706

MAS5
Mitochondrial protein import protein MAS5

2

3

Small-scale

0.571

High

638724

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

638712

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.536

High

638733

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

638732

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.513

High

638740

MCA1
Metacaspase-1

1

0

Small-scale

0.513

High

638721

LCF2
Long-chain-fatty-acid--CoA ligase 2

1

1

High-throughput

0.508

High

638707

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.504

High

481480

HSP73
Heat shock protein SSA3

1

3

Small-scale

0.481

High

638702

HSP74
Heat shock protein SSA4

1

3

Small-scale

0.481

High

638745

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.481

High

517892

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

486027

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.479

High

486405

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.479

High

626582

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.479

High

638703

TRX1
Thioredoxin-1

1

1

High-throughput

0.479

High

638704

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

638708

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

638709

MCM4
DNA replication licensing factor MCM4

1

1

Small-scale

0.479

High

638713

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

638736

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

638744

WTM2
Transcriptional modulator WTM2

1

1

High-throughput

0.479

High

638747

WTM1
Transcriptional modulator WTM1

1

1

High-throughput

0.479

High

638749

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

638715

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

638716

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.458

High

638718

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

638722

AIM2
Protein AIM2

1

0

High-throughput

0.458

High

638730

BPL1
Biotin--protein ligase

1

0

High-throughput

0.458

High

638734

ESP1
Separin

1

0

High-throughput

0.458

High

638735

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

638738

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

638739

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

638741

FOLE
Folylpolyglutamate synthase

1

0

Small-scale

0.458

High

638743

YO283
Broad-specificity phosphatase YOR283W

1

0

High-throughput

0.458

High

638748

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

638751

DET1
Broad-range acid phosphatase DET1

1

0

High-throughput

0.458

High

638727

BNI1
Protein BNI1

1

1

High-throughput

0.457

High

543807

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

638705

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.445

High

638710

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

638711

HSP79
Heat shock protein homolog SSE2

1

5

High-throughput

0.445

High

638720

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

638746

HSP42
Heat shock protein 42

1

2

High-throughput

0.445

High

638714

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

638723

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

638729

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

638750

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.426

High

638726

JEM1
DnaJ-like chaperone JEM1

1

3

High-throughput

0.407

High

638719

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

638725

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

638742

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025