HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

The method score is based on:

Property	Details
Experiments	32912968, 18276832
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_5~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 5 others more... GO:0007249 - canonical NF-kappaB signal transduction GO:0031663 - lipopolysaccharide-mediated signaling pathway GO:0032088 - negative regulation of NF-kappaB transcription factor activity GO:0034142 - toll-like receptor 4 signaling pathway GO:0070498 - interleukin-1-mediated signaling pathway
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	317
Hs

1	712

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024