Protein: YBEY
Endoribonuclease YbeY (EC 3.1.-.-)

Gene: YBEY
Organism: Homo sapiens
Interactions: 98
UniProt ID: P58557

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006364 - rRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586600

RS2
Small ribosomal subunit protein uS5

3

1

High-throughput

0.667

High

188571

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

3

0

High-throughput

0.638

High

238704

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

2

2

High-throughput

0.628

High

725595

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

2

3

High-throughput

0.628

High

856230

IF2M
Translation initiation factor IF-2, mitochondrial

2

1

High-throughput

0.628

High

946488

SYLM
Leucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.628

High

946505

GTPB8
GTP-binding protein 8

2

1

High-throughput

0.628

High

946513

RRF2M
Ribosome-releasing factor 2, mitochondrial

2

2

High-throughput

0.628

High

946520

EFGM
Elongation factor G, mitochondrial

2

2

High-throughput

0.628

High

946538

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

2

1

High-throughput

0.628

High

946544

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

2

2

High-throughput

0.628

High

946545

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

2

2

High-throughput

0.628

High

946492

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.611

High

143821

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.602

High

289768

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

2

0

High-throughput

0.602

High

322221

GLSK
Glutaminase kidney isoform, mitochondrial

2

0

High-throughput

0.602

High

532489

CH60
60 kDa heat shock protein, mitochondrial

2

0

High-throughput

0.602

High

649875

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

2

0

High-throughput

0.602

High

884621

SYHM
Histidine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

926073

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

935830

ECHB
Trifunctional enzyme subunit beta, mitochondrial

2

0

High-throughput

0.602

High

946484

ABD18
Protein ABHD18

2

0

High-throughput

0.602

High

946485

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.602

High

946487

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

2

0

High-throughput

0.602

High

946494

PPCEL
Prolyl endopeptidase-like

2

0

High-throughput

0.602

High

946497

ACD10
Acyl-CoA dehydrogenase family member 10

2

0

High-throughput

0.602

High

946500

SYDM
Aspartate--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

946502

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

2

0

High-throughput

0.602

High

946503

THNS1
Threonine synthase-like 1

2

0

High-throughput

0.602

High

946508

CHDH
Choline dehydrogenase, mitochondrial

2

0

High-throughput

0.602

High

946511

SSH3
Protein phosphatase Slingshot homolog 3

2

0

High-throughput

0.602

High

946512

TFB1M
Dimethyladenosine transferase 1, mitochondrial

2

0

High-throughput

0.602

High

946514

DDX11
ATP-dependent DNA helicase DDX11

2

0

High-throughput

0.602

High

946522

RNZ2
Zinc phosphodiesterase ELAC protein 2

2

0

High-throughput

0.602

High

946524

CQ080
Mitochondrial nucleoid-associated protein 1

2

0

High-throughput

0.602

High

946525

MTG1
Mitochondrial ribosome-associated GTPase 1

2

0

High-throughput

0.602

High

946534

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

946536

PAPD1
Poly(A) RNA polymerase, mitochondrial

2

0

High-throughput

0.602

High

946539

TRM1
tRNA

2

0

High-throughput

0.602

High

946542

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

2

0

High-throughput

0.602

High

425790

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.536

High

547117

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.536

High

946507

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

1

High-throughput

0.536

High

946515

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

946521

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

946535

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

1

High-throughput

0.536

High

946543

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

1

High-throughput

0.536

High

71718

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.513

High

177529

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

229130

GTPB6
Putative GTP-binding protein 6

1

0

High-throughput

0.513

High

380830

MYG
Myoglobin

1

0

High-throughput

0.513

High

829334

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.513

High

853208

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.513

High

920692

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.513

High

946483

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

High-throughput

0.513

High

946489

PDK3
[Pyruvate dehydrogenase

1

0

High-throughput

0.513

High

946495

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.513

High

946498

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.513

High

946506

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

946516

OXND1
Oxidoreductase NAD-binding domain-containing protein 1

1

0

High-throughput

0.513

High

946517

DHTK1
2-oxoadipate dehydrogenase complex component E1

1

0

High-throughput

0.513

High

946518

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.513

High

946523

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

1

0

High-throughput

0.513

High

946527

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.513

High

946531

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.513

High

946541

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.513

High

946546

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

933812

GEM
GTP-binding protein GEM

1

0

High-throughput

0.486

High

342142

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

363057

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

639700

TAF1
Transcription initiation factor TFIID subunit 1

1

1

High-throughput

0.479

High

299636

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.458

High

504871

H2AB2
Histone H2A-Bbd type 2/3

1

0

High-throughput

0.458

High

946482

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

0

High-throughput

0.458

High

946499

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.458

High

946501

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

946504

ZN444
Zinc finger protein 444

1

0

High-throughput

0.458

High

946519

NSL1
Kinetochore-associated protein NSL1 homolog

1

0

High-throughput

0.458

High

946526

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.458

High

946532

ZN644
Zinc finger protein 644

1

0

High-throughput

0.458

High

946547

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

946533

AKTIP
AKT-interacting protein

1

0

High-throughput

0.438

High

641541

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

1

High-throughput

0.437

High

946510

DMXL2
DmX-like protein 2

2

0

High-throughput

0.328

High

946486

KT33B
Keratin, type I cuticular Ha3-II

1

0

High-throughput

0.279

Low

946491

CART

1

0

High-throughput

0.279

Low

946509

GA2L2
GAS2-like protein 2

1

0

High-throughput

0.279

Low

946537

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.279

Low

946540

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

293451

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

329913

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.249

Low

942517

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

946490

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.249

Low

946493

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.249

Low

946496

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

946528

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.249

Low

946529

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.249

Low

946530

TMPS5
Transmembrane protease serine 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025