HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.966

The method score is based on:

Property Details
Experiments 35271311, 26186194, 26496610, 28514442, 32912968, 33961781, 14743216
Identification Methods affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Ank_2, Ank_2~RHD_dimer, Ank_2~Ank_5
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007249 - canonical NF-kappaB signal transduction
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 317
Hs

1 900
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Last updated: 15 Jul 2024