HitPredict - High confidence protein-protein interactions

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.99	1.00	0.998

Property	Details
Experiments	10085161, 25520503, 25609694, 26463447, 26476452, 27923823, 23185316, 29084252, 27609421, 10498867, 29439025, 30213788, 12419806, 30628021, 30542119, 9990853, 8139561, 33060567, 9738011, 33478005 and 69 others more... 33754058, 35271311, 37055579, 7878004, 8887633, 8978697, 7628694, 20065107, 20551178, 22081069, 8657102, 14690596, 15799966, 8887627, 23563313, 7739549, 9572494, 26186194, 26496610, 28514442, 11533489, 20876301, 11313474, 32912968, 33961781, 9751059, 33460751, 32391793, 19219072, 16105840, 20980497, 11231305, 11287411, 10066434, 20797629, 22022389, 11020244, 21988832, 17003112, 24248593, 14743216, 17301240, 14685242, 1340770, 15657065, 15671248, 15226358, 15845455, 12820969, 18276832, 9135156, 15722553, 16226509, 15024091, 12927781, 19020113, 16209943, 16280327, 18045535, 21399639, 24634218, 16683270, 25759022, 29734393, 21217772, 17612295, 16951195, 23850221, 24457201
Identification Methods	affinity chromatography technology, two hybrid, pull down, proximity labelling technology, enzymatic study, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, rna immunoprecipitation, protein kinase assay and 2 others more... ubiquitin reconstruction, two hybrid array
Interaction Type	physical association, direct interaction, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007249 - canonical NF-kappaB signal transduction and 12 others more... GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0032495 - response to muramyl dipeptide GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0034142 - toll-like receptor 4 signaling pathway GO:0035994 - response to muscle stretch GO:0038061 - non-canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051059 - NF-kappaB binding GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070498 - interleukin-1-mediated signaling pathway GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	317
Hs

1	551

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Last updated: 15 Jul 2024