Protein: TAF1
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)

Gene: TAF1
Organism: Homo sapiens
Interactions: 234
UniProt ID: P21675

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091 - RNA polymerase II general transcription initiation factor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628696

TBP
TATA-box-binding protein

19

14

Small-scale

0.986

High

639749

TAF7L
Transcription initiation factor TFIID subunit 7-like

5

6

Small-scale

0.921

High

639739

TAF7
Transcription initiation factor TFIID subunit 7

4

6

Small-scale

0.884

High

639754

TAF3
Transcription initiation factor TFIID subunit 3

3

15

Small-scale

0.847

High

639734

BRD3
Bromodomain-containing protein 3

2

19

High-throughput

0.776

High

639666

BRD2
Bromodomain-containing protein 2

2

20

High-throughput

0.754

High

639766

TAF8
Transcription initiation factor TFIID subunit 8

7

4

Small-scale

0.742

High

639676

T2FA
General transcription factor IIF subunit 1

5

1

Small-scale

0.721

High

442587

RB
Retinoblastoma-associated protein

4

6

Small-scale

0.714

High

639852

ASF1A
Histone chaperone ASF1A

1

10

Small-scale

0.710

High

639710

H31
Histone H3.1

5

20

Small-scale

0.707

High

639834

BRWD1
Bromodomain and WD repeat-containing protein 1

1

19

High-throughput

0.698

High

639723

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.691

High

130700

TAF4
Transcription initiation factor TFIID subunit 4

4

13

Small-scale

0.689

High

639705

H4
Histone H4

4

20

Small-scale

0.683

High

639686

TAF6
Transcription initiation factor TFIID subunit 6

4

14

Small-scale

0.680

High

639756

TAF2
Transcription initiation factor TFIID subunit 2

4

7

Small-scale

0.680

High

639736

TAF5
Transcription initiation factor TFIID subunit 5

4

20

Small-scale

0.676

High

639826

TAF9B
Transcription initiation factor TFIID subunit 9B

3

12

Small-scale

0.656

High

639742

TAF12
Transcription initiation factor TFIID subunit 12

3

11

High-throughput

0.650

High

639791

TAF4B
Transcription initiation factor TFIID subunit 4B

3

18

Small-scale

0.646

High

639724

TAF10
Transcription initiation factor TFIID subunit 10

3

13

Small-scale

0.646

High

639737

TAF13
Transcription initiation factor TFIID subunit 13

3

6

Small-scale

0.640

High

639745

TAF9
Transcription initiation factor TFIID subunit 9

3

12

Small-scale

0.640

High

639703

WDR5
WD repeat-containing protein 5

3

16

Small-scale

0.633

High

519740

ANDR
Androgen receptor

2

20

Small-scale

0.631

High

639664

CCND1
G1/S-specific cyclin-D1

2

17

Small-scale

0.629

High

413183

P53
Cellular tumor antigen p53

2

20

Small-scale

0.624

High

259438

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.618

High

639662

TAF1
Transcription initiation factor TFIID subunit 1

1

19

Small-scale

0.618

High

639688

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

Small-scale

0.618

High

639696

BRPF1
Peregrin

1

20

High-throughput

0.618

High

639704

TBPL1
TATA box-binding protein-like 1

1

14

High-throughput

0.618

High

639717

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.618

High

639727

PEX6
Peroxisomal ATPase PEX6

1

12

High-throughput

0.618

High

639738

TAF11
Transcription initiation factor TFIID subunit 11

1

4

Small-scale

0.618

High

639789

PHIP
PH-interacting protein

1

20

High-throughput

0.618

High

639795

PF21A
PHD finger protein 21A

1

20

High-throughput

0.618

High

639802

WRIP1
ATPase WRNIP1

1

4

High-throughput

0.618

High

639819

BRD8
Bromodomain-containing protein 8

1

19

High-throughput

0.618

High

639845

BRPF3
Bromodomain and PHD finger-containing protein 3

1

20

High-throughput

0.618

High

639850

PHF8
Histone lysine demethylase PHF8

1

11

Small-scale

0.618

High

421497

A4
Amyloid-beta precursor protein

2

8

High-throughput

0.608

High

639715

MDM2
E3 ubiquitin-protein ligase Mdm2

2

6

Small-scale

0.595

High

639718

TF65
Transcription factor p65

2

20

Small-scale

0.595

High

639782

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

0

High-throughput

0.585

High

371156

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

639843

RCOR1
REST corepressor 1

2

20

High-throughput

0.584

High

639663

PAX3
Paired box protein Pax-3

1

20

Small-scale

0.578

High

639746

H31T
Histone H3.1t

2

20

Small-scale

0.563

High

639842

LHX3
LIM/homeobox protein Lhx3

1

15

Small-scale

0.561

High

604594

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.552

High

639786

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.549

High

298885

DNJB5
DnaJ homolog subfamily B member 5

1

7

High-throughput

0.541

High

317397

KPCD3
Serine/threonine-protein kinase D3

1

12

High-throughput

0.541

High

639665

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.541

High

639685

RBP2
E3 SUMO-protein ligase RanBP2

1

7

High-throughput

0.541

High

639693

TTC3
E3 ubiquitin-protein ligase TTC3

1

12

High-throughput

0.541

High

639697

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

9

High-throughput

0.541

High

639701

MAX
Protein max

1

20

High-throughput

0.541

High

639752

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

13

High-throughput

0.541

High

639779

CLIP4
CAP-Gly domain-containing linker protein 4

1

5

High-throughput

0.541

High

639800

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.541

High

335955

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

High-throughput

0.536

High

639681

MAGA9
Melanoma-associated antigen 9

1

11

High-throughput

0.536

High

639683

CDK8
Cyclin-dependent kinase 8

1

19

High-throughput

0.536

High

639748

TFDP3
Transcription factor Dp family member 3

1

1

High-throughput

0.536

High

639806

NPAS1
Neuronal PAS domain-containing protein 1

1

20

High-throughput

0.536

High

639822

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.536

High

639698

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

639730

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

261473

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

639753

GFI1B
Zinc finger protein Gfi-1b

1

10

High-throughput

0.508

High

639830

BRMS1
Breast cancer metastasis-suppressor 1

1

7

Small-scale

0.508

High

370561

FOS
Protein c-Fos

1

20

Small-scale

0.501

High

429298

JUN
Transcription factor Jun

1

20

Small-scale

0.501

High

639702

SUMO2
Small ubiquitin-related modifier 2

1

11

High-throughput

0.501

High

639708

UBC9
SUMO-conjugating enzyme UBC9

1

12

Small-scale

0.501

High

639716

H11
Histone H1.1

1

13

Small-scale

0.501

High

297334

DYSF
Dysferlin

1

5

High-throughput

0.494

High

612035

ITB5
Integrin beta-5

1

2

High-throughput

0.494

High

639695

MYOM2
Myomesin-2

1

5

High-throughput

0.494

High

639817

DOCK9
Dedicator of cytokinesis protein 9

1

2

High-throughput

0.494

High

484376

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.493

High

639679

LIFR
Leukemia inhibitory factor receptor

1

3

High-throughput

0.489

High

639792

KIFA3
Kinesin-associated protein 3

1

20

High-throughput

0.489

High

639854

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

639672

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.480

High

639692

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

124234

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.479

High

128774

MEN1
Menin

1

7

Small-scale

0.479

High

142832

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

190817

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

246431

KDM1A
Lysine-specific histone demethylase 1A

1

10

High-throughput

0.479

High

325683

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

High-throughput

0.479

High

331961

KAT7
Histone acetyltransferase KAT7

1

20

High-throughput

0.479

High

334506

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

20

High-throughput

0.479

High

336215

ZIC2
Zinc finger protein ZIC 2

1

11

High-throughput

0.479

High

342747

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

462846

LAMB1
Laminin subunit beta-1

1

7

High-throughput

0.479

High

473785

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

517515

GLI3
Transcriptional activator GLI3

1

12

High-throughput

0.479

High

557857

XRCC6
X-ray repair cross-complementing protein 6

1

15

High-throughput

0.479

High

639667

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

639668

RBTN2
Rhombotin-2

1

17

Small-scale

0.479

High

639669

PAX6
Paired box protein Pax-6

1

15

Small-scale

0.479

High

639670

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

Small-scale

0.479

High

639671

RBL1
Retinoblastoma-like protein 1

1

6

Small-scale

0.479

High

639673

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.479

High

639674

CDC27
Cell division cycle protein 27 homolog

1

19

Small-scale

0.479

High

639675

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

639677

COIL
Coilin

1

2

High-throughput

0.479

High

639678

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

639680

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

17

High-throughput

0.479

High

639682

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

639684

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

639687

CDK7
Cyclin-dependent kinase 7

1

9

High-throughput

0.479

High

639689

IRAK1
Interleukin-1 receptor-associated kinase 1

1

4

High-throughput

0.479

High

639691

JAK3
Tyrosine-protein kinase JAK3

1

20

High-throughput

0.479

High

639694

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

639699

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

639700

YBEY
Endoribonuclease YbeY

1

1

High-throughput

0.479

High

639706

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.479

High

639709

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.479

High

639712

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

639713

H33
Histone H3.3

1

20

High-throughput

0.479

High

639721

RBL2
Retinoblastoma-like protein 2

1

6

Small-scale

0.479

High

639722

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

639725

ATM
Serine-protein kinase ATM

1

20

High-throughput

0.479

High

639726

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

639729

KEAP1
Kelch-like ECH-associated protein 1

1

4

High-throughput

0.479

High

639733

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

639740

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

639741

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

639747

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

8

High-throughput

0.479

High

639750

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

3

High-throughput

0.479

High

639751

ZN362
Zinc finger protein 362

1

5

High-throughput

0.479

High

639757

GLD2
Poly(A) RNA polymerase GLD2

1

5

High-throughput

0.479

High

639758

RICTR
Rapamycin-insensitive companion of mTOR

1

7

High-throughput

0.479

High

639759

TSSK4
Testis-specific serine/threonine-protein kinase 4

1

5

High-throughput

0.479

High

639760

SAMD1
Sterile alpha motif domain-containing protein 1

1

18

High-throughput

0.479

High

639764

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

639765

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

3

High-throughput

0.479

High

639767

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

16

Small-scale

0.479

High

639768

LDB1
LIM domain-binding protein 1

1

2

Small-scale

0.479

High

639769

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

639770

KSR1
Kinase suppressor of Ras 1

1

8

High-throughput

0.479

High

639771

DHX40
Probable ATP-dependent RNA helicase DHX40

1

14

High-throughput

0.479

High

639774

SMC5
Structural maintenance of chromosomes protein 5

1

20

High-throughput

0.479

High

639775

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

4

High-throughput

0.479

High

639777

RCOR2
REST corepressor 2

1

20

High-throughput

0.479

High

639778

ABCA7
Phospholipid-transporting ATPase ABCA7

1

1

High-throughput

0.479

High

639780

ANR42
Ankyrin repeat domain-containing protein 42

1

7

High-throughput

0.479

High

639783

COQ8A
Atypical kinase COQ8A, mitochondrial

1

6

High-throughput

0.479

High

639785

FEZF2
Fez family zinc finger protein 2

1

8

High-throughput

0.479

High

639787

BRSK1
Serine/threonine-protein kinase BRSK1

1

11

High-throughput

0.479

High

639794

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

20

High-throughput

0.479

High

639796

SIPA1
Signal-induced proliferation-associated protein 1

1

2

High-throughput

0.479

High

639797

AURKB
Aurora kinase B

1

8

High-throughput

0.479

High

639801

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

639803

SIN3A
Paired amphipathic helix protein Sin3a

1

7

Small-scale

0.479

High

639804

HTF4
Transcription factor 12

1

13

High-throughput

0.479

High

639805

FEV
Protein FEV

1

20

High-throughput

0.479

High

639807

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

639811

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.479

High

639812

DDX23
Probable ATP-dependent RNA helicase DDX23

1

14

High-throughput

0.479

High

639813

GNL3
Guanine nucleotide-binding protein-like 3

1

10

High-throughput

0.479

High

639814

DDA1
DET1- and DDB1-associated protein 1

1

4

High-throughput

0.479

High

639815

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

639818

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

4

High-throughput

0.479

High

639820

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

639821

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

639823

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.479

High

639825

SP110
Sp110 nuclear body protein

1

20

High-throughput

0.479

High

639829

TF7L1
Transcription factor 7-like 1

1

20

High-throughput

0.479

High

639831

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

639837

UCKL1
Uridine-cytidine kinase-like 1

1

1

High-throughput

0.479

High

639838

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

2

High-throughput

0.479

High

639839

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

6

High-throughput

0.479

High

639840

MYEF2
Myelin expression factor 2

1

12

High-throughput

0.479

High

639841

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.479

High

639844

NUP50
Nuclear pore complex protein Nup50

1

8

High-throughput

0.479

High

639847

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

2

High-throughput

0.479

High

639848

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.479

High

639849

AKP8L
A-kinase anchor protein 8-like

1

9

High-throughput

0.479

High

639853

ZN330
Zinc finger protein 330

1

6

High-throughput

0.479

High

639720

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.470

High

639784

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.458

High

639810

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.458

High

639816

BEX2
Protein BEX2

1

0

Small-scale

0.458

High

639719

FMR1
Fragile X messenger ribonucleoprotein 1

1

9

High-throughput

0.457

High

639832

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

639690

IMA1
Importin subunit alpha-1

1

20

High-throughput

0.445

High

639707

RL10A
Large ribosomal subunit protein uL1

1

4

High-throughput

0.445

High

639728

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

12

Small-scale

0.439

High

162084

ACOT8
Acyl-coenzyme A thioesterase 8

1

3

High-throughput

0.437

High

228798

SCO2
Protein SCO2 homolog, mitochondrial

1

6

High-throughput

0.437

High

471534

CD14
Monocyte differentiation antigen CD14

1

1

High-throughput

0.437

High

639711

3BP2
SH3 domain-binding protein 2

1

2

High-throughput

0.437

High

639714

BORG5
Cdc42 effector protein 1

1

1

High-throughput

0.437

High

639731

RCN2
Reticulocalbin-2

1

18

High-throughput

0.437

High

639732

GSE1
Genetic suppressor element 1

1

3

High-throughput

0.437

High

639735

EEA1
Early endosome antigen 1

1

18

High-throughput

0.437

High

639743

B2LA1
Bcl-2-related protein A1

1

6

Small-scale

0.437

High

639755

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

1

High-throughput

0.437

High

639761

UNC5D
Netrin receptor UNC5D

1

1

High-throughput

0.437

High

639762

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

639763

AN13D
Ankyrin repeat domain-containing protein 13D

1

10

High-throughput

0.437

High

639772

MIRO2
Mitochondrial Rho GTPase 2

1

6

High-throughput

0.437

High

639781

S4A11
Solute carrier family 4 member 11

1

1

High-throughput

0.437

High

639788

FBF1
Fas-binding factor 1

1

20

High-throughput

0.437

High

639793

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

6

High-throughput

0.437

High

639799

TMX3
Protein disulfide-isomerase TMX3

1

10

High-throughput

0.437

High

639809

CAB45
45 kDa calcium-binding protein

1

17

High-throughput

0.437

High

639824

FBRS
Probable fibrosin-1

1

4

High-throughput

0.437

High

639827

K1549
UPF0606 protein KIAA1549

1

18

High-throughput

0.437

High

639828

FBSL
Fibrosin-1-like protein

1

4

High-throughput

0.437

High

639835

EMIL3
EMILIN-3

1

9

High-throughput

0.437

High

639836

TM248
Transmembrane protein 248

1

1

High-throughput

0.437

High

639851

PZRN3
E3 ubiquitin-protein ligase PDZRN3

1

6

High-throughput

0.437

High

639855

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

4

High-throughput

0.437

High

639808

SPT25
Spermatogenesis-associated protein 25

2

0

High-throughput

0.313

High

639744

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.282

High

639773

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

639833

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.279

Low

66867

SPDE4
Speedy protein E4

1

0

High-throughput

0.249

Low

84333

B6ZDN3
Doublecortin domain containing 1

1

0

High-throughput

0.249

Low

569157

HRES1
Putative HTLV-1-related endogenous sequence

1

0

High-throughput

0.249

Low

639776

BD1L2
Biorientation of chromosomes in cell division protein 1-like 2

1

0

High-throughput

0.249

Low

639790

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.249

Low

639798

PAGE5
P antigen family member 5

1

0

High-throughput

0.249

Low

639846

INTU
Protein inturned

1

0

High-throughput

0.249

Low

516937

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025