HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19596990
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 258
+	Hs
		147393 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		433258 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		YES_HUMAN (50-213): 3.31e-43: 155: 16.28
+	Hs
		522789 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Hs
		639676 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Mm
		140058 NFKB1_MOUSE (70-302): 5.46e-66: 224: 38.98		P85B_MOUSE (52-196): 8.55e-22: 96.1: 17.93
+	Hs
		412002 BCL3_HUMAN (26-234): 3e-29: 118: 24.76		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		411697 ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		411590 BCL3_HUMAN (26-234): 3e-29: 118: 24.76		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		147387 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		411885 KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		433701 ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21
+	Hs
		883587 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		P55G_HUMAN (53-183): 1.06e-21: 95.3: 15.27
+	Hs
		655290 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		1267436 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		P55G_HUMAN (53-183): 1.06e-21: 95.3: 15.27
+	Hs
		655466 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Mm
		103593 ANK3_MOUSE (1-130): 6.93e-29: 118: 10.77		P85A_MOUSE (52-188): 4.14e-21: 94.1: 16.06
+	Hs
		433730 ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21
+	Hs
		1267413 ANS1A_HUMAN (173-293): 8.47e-20: 92: 20.16		P55G_HUMAN (53-183): 1.06e-21: 95.3: 15.27
+	Hs
		434071 KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21
+	Hs
		434072 ANR50_HUMAN (2-66): 2.02e-09: 60.6: 4.62		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21