HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: HIF1N (Q9NWT6)
Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)
Gene: HIF1AN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 0.60 0.724

The method score is based on:

Property Details
Experiments 26972000, 26186194, 28514442, 33961781, 17003112
Identification Methods affinity chromatography technology, hydroxylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association, hydroxylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0045746 - negative regulation of Notch signaling pathway
GO:0051059 - NF-kappaB binding
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 317
Hs

1 349
+ Hs
+ Dr
+ Dr
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024