HitPredict

Interactor 1: ITA3 (P26006)
Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
Gene: ITGA3

Interactor 2: CD151 (P48509)
CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)
Gene: CD151

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	10734060, 22495828, 33961781, 10811835, 14557253
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1051 Hs			1 253
+	Hs
		639879 ITA3_HUMAN (1-1051): 0: 1223: 100.00		TSN5_HUMAN (3-250): 3e-63: 200: 23.40
+	Hs
		639894 ITA3_HUMAN (1-1051): 0: 1223: 100.00		TSN14_HUMAN (4-250): 2.18e-59: 190: 23.86
+	Mm
		192879 ITA3_MOUSE (1-1051): 0: 1196: 87.65		CD151_MOUSE (1-253): 2.45e-66: 207: 93.68
+	Hs
		326026 ITA3_HUMAN (1-1051): 0: 1223: 100.00		TSN15_HUMAN (15-250): 9.71e-50: 166: 23.39
+	Hs
		602219 ITA3_HUMAN (1-1051): 0: 1223: 100.00		CD9_HUMAN (9-251): 1.52e-49: 164: 29.44
+	Hs
		156133 ITA3_HUMAN (1-1051): 0: 1223: 100.00		TSN4_HUMAN (8-248): 7.87e-47: 157: 31.54
+	Hs
		326269 ITA3_HUMAN (1-1051): 0: 1223: 100.00		TSN12_HUMAN (13-248): 3.56e-46: 157: 27.09
+	Hs
		613224 ITA6_HUMAN (11-1043): 0: 1027: 35.75		CD151_HUMAN (1-253): 6.35e-74: 227: 100.00
+	Hs
		50294 ITA6_HUMAN (11-1043): 0: 1027: 35.75		TSN11_HUMAN (1-253): 4.04e-73: 225: 56.13
+	Hs
		819448 ITA7_HUMAN (1-1043): 0: 1001: 33.85		CD151_HUMAN (1-253): 6.35e-74: 227: 100.00
+	Hs
		613235 ITA6_HUMAN (11-1043): 0: 1027: 35.75		TSN5_HUMAN (3-250): 3e-63: 200: 23.40
+	Hs
		50296 ITA7_HUMAN (1-1043): 0: 1001: 33.85		TSN11_HUMAN (1-253): 4.04e-73: 225: 56.13
+	Hs
		613229 ITA6_HUMAN (11-1043): 0: 1027: 35.75		CD81_HUMAN (9-250): 5.01e-54: 176: 23.70
+	Hs
		326024 ITA6_HUMAN (11-1043): 0: 1027: 35.75		TSN15_HUMAN (15-250): 9.71e-50: 166: 23.39
+	Hs
		602217 ITA6_HUMAN (11-1043): 0: 1027: 35.75		CD9_HUMAN (9-251): 1.52e-49: 164: 29.44
+	Hs
		156132 ITA6_HUMAN (11-1043): 0: 1027: 35.75		TSN4_HUMAN (8-248): 7.87e-47: 157: 31.54
+	Hs
		613274 ITA6_HUMAN (11-1043): 0: 1027: 35.75		TSN18_HUMAN (15-249): 4.56e-19: 85.1: 29.92
+	Hs
		530541 ITA4_HUMAN (3-1050): 0: 898: 22.77		CD81_HUMAN (9-250): 5.01e-54: 176: 23.70
+	Hs
		419182 ITAV_HUMAN (30-1021): 0: 854: 25.26		CD81_HUMAN (9-250): 5.01e-54: 176: 23.70
+	Hs
		443039 ITA5_HUMAN (7-1038): 0: 819: 25.67		CD9_HUMAN (9-251): 1.52e-49: 164: 29.44