Protein: UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)

Gene: UCHL3
Organism: Homo sapiens
Interactions: 125
UniProt ID: P15374

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475307

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

26

15

Small-scale

0.992

High

548102

NEDD8
NEDD8

3

14

Small-scale

0.858

High

548050

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

2

6

Small-scale

0.737

High

548125

CLPB
Mitochondrial disaggregase

4

1

High-throughput

0.697

High

474910

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

15

Small-scale

0.647

High

548107

Q5U5U6
Epididymis secretory protein Li 50

1

15

Small-scale

0.647

High

548091

RAD51
DNA repair protein RAD51 homolog 1

2

1

Small-scale

0.639

High

548124

TRI55
Tripartite motif-containing protein 55

2

19

High-throughput

0.619

High

226429

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

548135

UBQL1
Ubiquilin-1

1

8

High-throughput

0.618

High

548113

CSN5
COP9 signalosome complex subunit 5

2

12

Small-scale

0.601

High

548114

TRI63
E3 ubiquitin-protein ligase TRIM63

2

18

High-throughput

0.594

High

243871

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

548069

YAP1
Transcriptional coactivator YAP1

1

4

Small-scale

0.578

High

548106

RHGBB
Inactive Rho GTPase-activating protein 11B

2

2

High-throughput

0.571

High

548128

RHG35
Rho GTPase-activating protein 35

2

2

High-throughput

0.571

High

524779

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.561

High

548092

FOXM1
Forkhead box protein M1

1

5

Small-scale

0.561

High

548101

SMAD1
Mothers against decapentaplegic homolog 1

1

7

Small-scale

0.515

High

548109

CSN6
COP9 signalosome complex subunit 6

1

7

High-throughput

0.515

High

548137

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

14

High-throughput

0.515

High

548110

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

3

High-throughput

0.515

High

538463

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.501

High

548096

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

548112

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

High-throughput

0.501

High

548118

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

12

High-throughput

0.501

High

548123

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.501

High

548134

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

10

High-throughput

0.501

High

548139

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

9

High-throughput

0.501

High

548131

POGK
Pogo transposable element with KRAB domain

1

0

High-throughput

0.486

High

536719

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.481

High

548105

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

13

High-throughput

0.481

High

548104

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

117089

DX39A
ATP-dependent RNA helicase DDX39A

1

7

Small-scale

0.479

High

133303

NOP56
Nucleolar protein 56

1

3

Small-scale

0.479

High

133869

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

160358

AURKA
Aurora kinase A

1

5

Small-scale

0.479

High

324209

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

325018

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

Small-scale

0.479

High

340368

PGK1
Phosphoglycerate kinase 1

1

2

Small-scale

0.479

High

359461

K2C6A
Keratin, type II cytoskeletal 6A

1

9

Small-scale

0.479

High

408725

K1C18
Keratin, type I cytoskeletal 18

1

8

Small-scale

0.479

High

417136

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

431500

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

443303

VIME
Vimentin

1

11

Small-scale

0.479

High

503371

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

508318

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.479

High

523494

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

538086

ENPL
Endoplasmin

1

6

Small-scale

0.479

High

540887

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

6

Small-scale

0.479

High

541302

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

Small-scale

0.479

High

548051

DDX5
Probable ATP-dependent RNA helicase DDX5

1

6

Small-scale

0.479

High

548052

LMNB1
Lamin-B1

1

8

Small-scale

0.479

High

548054

RL13
Large ribosomal subunit protein eL13

1

2

Small-scale

0.479

High

548055

EF1G
Elongation factor 1-gamma

1

4

Small-scale

0.479

High

548056

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

3

Small-scale

0.479

High

548059

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

Small-scale

0.479

High

548061

CTNB1
Catenin beta-1

1

8

High-throughput

0.479

High

548062

AHR
Aryl hydrocarbon receptor

1

3

Small-scale

0.479

High

548064

IF4A3
Eukaryotic initiation factor 4A-III

1

9

Small-scale

0.479

High

548065

TCPZ
T-complex protein 1 subunit zeta

1

6

Small-scale

0.479

High

548066

MDHM
Malate dehydrogenase, mitochondrial

1

5

Small-scale

0.479

High

548068

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.479

High

548070

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

548071

FAS
Fatty acid synthase

1

2

Small-scale

0.479

High

548072

TCPG
T-complex protein 1 subunit gamma

1

7

Small-scale

0.479

High

548074

TCPD
T-complex protein 1 subunit delta

1

6

Small-scale

0.479

High

548075

FXR1
RNA-binding protein FXR1

1

3

Small-scale

0.479

High

548076

RAB7A
Ras-related protein Rab-7a

1

6

Small-scale

0.479

High

548078

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

3

Small-scale

0.479

High

548079

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

6

Small-scale

0.479

High

548080

IF4A1
Eukaryotic initiation factor 4A-I

1

7

Small-scale

0.479

High

548081

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.479

High

548082

RS15A
Small ribosomal subunit protein uS8

1

1

Small-scale

0.479

High

548083

ACTA
Actin, aortic smooth muscle

1

10

Small-scale

0.479

High

548084

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.479

High

548085

RL10A
Large ribosomal subunit protein uL1

1

3

Small-scale

0.479

High

548086

ACTG
Actin, cytoplasmic 2

1

11

Small-scale

0.479

High

548087

TBA4A
Tubulin alpha-4A chain

1

12

Small-scale

0.479

High

548088

TBB4B
Tubulin beta-4B chain

1

11

Small-scale

0.479

High

548089

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

Small-scale

0.479

High

548090

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.479

High

548093

SSRP1
FACT complex subunit SSRP1

1

5

Small-scale

0.479

High

548094

ILF2
Interleukin enhancer-binding factor 2

1

3

Small-scale

0.479

High

548095

ILF3
Interleukin enhancer-binding factor 3

1

5

Small-scale

0.479

High

548097

DX39B
Spliceosome RNA helicase DDX39B

1

8

Small-scale

0.479

High

548098

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

10

Small-scale

0.479

High

548100

NONO
Non-POU domain-containing octamer-binding protein

1

7

Small-scale

0.479

High

548108

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

548111

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

7

Small-scale

0.479

High

548117

AURKB
Aurora kinase B

1

5

Small-scale

0.479

High

548119

TCPH
T-complex protein 1 subunit eta

1

7

Small-scale

0.479

High

548120

H2B1N
Histone H2B type 1-N

1

2

Small-scale

0.479

High

548121

TBB6
Tubulin beta-6 chain

1

11

Small-scale

0.479

High

548126

RAB1B
Ras-related protein Rab-1B

1

3

Small-scale

0.479

High

548127

DDX21
Nucleolar RNA helicase 2

1

7

Small-scale

0.479

High

548132

LIMA1
LIM domain and actin-binding protein 1

1

4

Small-scale

0.479

High

548136

E41L3
Band 4.1-like protein 3

1

3

Small-scale

0.479

High

548140

SRPRB
Signal recognition particle receptor subunit beta

1

1

Small-scale

0.479

High

103696

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

116546

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

Small-scale

0.458

High

390054

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

548060

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

548063

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.458

High

548103

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

Small-scale

0.458

High

548115

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

548130

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

Small-scale

0.458

High

521705

CADH1
Cadherin-1

1

2

Small-scale

0.457

High

537557

PA2GA
Phospholipase A2, membrane associated

1

2

Small-scale

0.457

High

548116

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

518234

ADT3
ADP/ATP translocase 3

1

1

Small-scale

0.437

High

548058

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

Small-scale

0.437

High

548067

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

Small-scale

0.437

High

548077

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

3

Small-scale

0.437

High

548129

HELLS
Lymphoid-specific helicase

1

1

Small-scale

0.437

High

548133

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

Small-scale

0.437

High

548073

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

321965

ZMYM6
Zinc finger MYM-type protein 6

3

0

High-throughput

0.347

High

548099

AT7L3
Ataxin-7-like protein 3

1

0

High-throughput

0.282

High

548138

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.265

Low

316569

ACSL3
Fatty acid CoA ligase Acsl3

1

0

Small-scale

0.249

Low

548053

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low

548057

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

Small-scale

0.249

Low

548122

SFXN3
Sideroflexin-3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024