HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	32144273, 32884836, 26527279, 29568061, 34079125, 36089195
Identification Methods	unspecified method, pull down, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BAH~Histone
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1616 Hs			1 136
+	Hs
		641229 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		641193 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		641169 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Xl
		945537 P79922_XENLA (126-1616): 0: 1502: 70.07		H33_XENLA (1-136): 2.73e-61: 186: 96.32
+	Xl
		945601 P79922_XENLA (126-1616): 0: 1502: 70.07		Q92133_XENLA (1-136): 3.08e-61: 186: 98.53
+	Xl
		945420 P79922_XENLA (126-1616): 0: 1502: 70.07		H32_XENLA (1-136): 6.5e-61: 185: 99.27
+	Hs
		934930 PB1_HUMAN (42-1162): 0: 602: 15.37		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086201 PB1_HUMAN (42-1162): 0: 602: 15.37		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952441 PB1_HUMAN (42-1162): 0: 602: 15.37		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		828285 PB1_HUMAN (42-1162): 0: 602: 15.37		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Nc
		421242 Q3Y3Z1_NEUCR (1040-1604): 1.28e-120: 416: 22.53		H3_NEUCR (1-135): 2.36e-58: 178: 90.37
+	Hs
		935328 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		935380 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952703 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174693 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		935442 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Mm
		291727 DNM3A_MOUSE (1128-1326): 6.78e-37: 153: 17.87		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		935150 MINT_HUMAN (5-706): 1.98e-35: 150: 12.71		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952734 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		828439 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00