Protein: FLT3
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)

Gene: FLT3
Organism: Homo sapiens
Interactions: 201
UniProt ID: P36888

Gene Ontology (top 5):
GO:0001776 - leukocyte homeostasis
GO:0002318 - myeloid progenitor cell differentiation
GO:0002328 - pro-B cell differentiation
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

786977

FLT3
Receptor-type tyrosine-protein kinase FLT3

3

17

Small-scale

0.834

High

786981

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.812

High

699618

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.776

High

787006

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.770

High

193221

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.754

High

786979

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.724

High

787012

SLAP1
Src-like-adapter

1

20

Small-scale

0.724

High

409291

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

8

High-throughput

0.691

High

520765

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

8

High-throughput

0.691

High

787013

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.690

High

362190

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.647

High

439973

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.647

High

440418

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.647

High

463008

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.647

High

557144

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

635682

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.647

High

786982

CRK
Adapter molecule crk

1

20

Small-scale

0.647

High

786983

CRKL
Crk-like protein

1

20

Small-scale

0.647

High

786988

BLK
Tyrosine-protein kinase Blk

1

20

Small-scale

0.647

High

410672

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

155086

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.618

High

167840

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.618

High

443234

CDK1
Cyclin-dependent kinase 1

1

8

High-throughput

0.618

High

461218

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

463381

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

473374

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

486663

FGR
Tyrosine-protein kinase Fgr

1

20

Small-scale

0.618

High

631618

RAB6A
Ras-related protein Rab-6A

1

7

High-throughput

0.618

High

787001

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

787010

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.618

High

787059

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

7

Small-scale

0.618

High

787068

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.618

High

156011

SOCS6
Suppressor of cytokine signaling 6

1

20

Small-scale

0.579

High

787081

TENS1
Tensin-1

1

12

Small-scale

0.579

High

651193

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.561

High

764492

CTNB1
Catenin beta-1

1

3

Small-scale

0.561

High

787045

PHC2
Polyhomeotic-like protein 2

1

2

High-throughput

0.553

High

787079

LRC40
Leucine-rich repeat-containing protein 40

1

10

High-throughput

0.553

High

170684

CLGN
Calmegin

1

10

High-throughput

0.536

High

698441

CALX
Calnexin

1

10

High-throughput

0.536

High

787009

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.536

High

787082

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.536

High

787023

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.513

High

168500

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

7

Small-scale

0.512

High

787042

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

Small-scale

0.512

High

787115

NEMO
NF-kappa-B essential modulator

1

4

High-throughput

0.512

High

228453

LANC1
Glutathione S-transferase LANCL1

1

2

High-throughput

0.500

High

787053

PO210
Nuclear pore membrane glycoprotein 210

1

1

High-throughput

0.489

High

787078

GHC1
Mitochondrial glutamate carrier 1

1

3

High-throughput

0.489

High

122720

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.479

High

137668

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

5

High-throughput

0.479

High

158784

AP3D1
AP-3 complex subunit delta-1

1

8

High-throughput

0.479

High

221536

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

4

High-throughput

0.479

High

243560

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

7

High-throughput

0.479

High

255583

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

10

High-throughput

0.479

High

333954

SMC2
Structural maintenance of chromosomes protein 2

1

11

High-throughput

0.479

High

345452

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

403139

APOB
Apolipoprotein B-100

1

1

High-throughput

0.479

High

467879

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

10

High-throughput

0.479

High

507619

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

538535

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.479

High

566927

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

3

High-throughput

0.479

High

608840

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

10

High-throughput

0.479

High

612157

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

627275

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

4

High-throughput

0.479

High

786010

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

786978

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.479

High

786984

SYQ
Glutamine--tRNA ligase

1

3

High-throughput

0.479

High

786985

EMD
Emerin

1

6

High-throughput

0.479

High

786986

SERPH
Serpin H1

1

6

High-throughput

0.479

High

786990

SYRC
Arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

786991

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

7

High-throughput

0.479

High

786993

SYMC
Methionine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

786995

TMM33
Transmembrane protein 33

1

2

High-throughput

0.479

High

786999

ARF6
ADP-ribosylation factor 6

1

11

High-throughput

0.479

High

787003

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.479

High

787008

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

2

High-throughput

0.479

High

787011

NDK3
Nucleoside diphosphate kinase 3

1

2

High-throughput

0.479

High

787017

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.479

High

787019

SMC1A
Structural maintenance of chromosomes protein 1A

1

11

High-throughput

0.479

High

787022

SYK
Lysine--tRNA ligase

1

5

High-throughput

0.479

High

787025

PCH2
Pachytene checkpoint protein 2 homolog

1

4

High-throughput

0.479

High

787030

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

4

High-throughput

0.479

High

787033

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.479

High

787034

ECM29
Proteasome adapter and scaffold protein ECM29

1

8

High-throughput

0.479

High

787035

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.479

High

787038

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

787039

DHX30
ATP-dependent RNA helicase DHX30

1

7

High-throughput

0.479

High

787044

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.479

High

787050

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.479

High

787051

DDX54
ATP-dependent RNA helicase DDX54

1

14

High-throughput

0.479

High

787055

DNJC9
DnaJ homolog subfamily C member 9

1

19

High-throughput

0.479

High

787061

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

High-throughput

0.479

High

787063

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

9

High-throughput

0.479

High

787064

DDX27
Probable ATP-dependent RNA helicase DDX27

1

14

High-throughput

0.479

High

787071

PKP2
Plakophilin-2

1

9

High-throughput

0.479

High

787075

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

787076

DDX47
Probable ATP-dependent RNA helicase DDX47

1

9

High-throughput

0.479

High

787077

YTDC2
3'-5' RNA helicase YTHDC2

1

7

High-throughput

0.479

High

787085

HELLS
Lymphoid-specific helicase

1

9

High-throughput

0.479

High

787086

MDN1
Midasin

1

7

High-throughput

0.479

High

787087

DD19A
ATP-dependent RNA helicase DDX19A

1

4

High-throughput

0.479

High

787090

DDX56
Probable ATP-dependent RNA helicase DDX56

1

12

High-throughput

0.479

High

787092

SYLC
Leucine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.479

High

787093

DHCR7
7-dehydrocholesterol reductase

1

2

High-throughput

0.479

High

787095

SEC63
Translocation protein SEC63 homolog

1

13

High-throughput

0.479

High

787098

BAZ1B
Tyrosine-protein kinase BAZ1B

1

9

High-throughput

0.479

High

787101

TTF2
Transcription termination factor 2

1

13

High-throughput

0.479

High

787102

SMC3
Structural maintenance of chromosomes protein 3

1

11

High-throughput

0.479

High

787108

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.479

High

787109

HYOU1
Hypoxia up-regulated protein 1

1

15

High-throughput

0.479

High

787110

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

2

High-throughput

0.479

High

787114

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.479

High

208190

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.458

High

786987

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.458

High

787018

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.458

High

787021

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

787024

PUM3
Pumilio homolog 3

1

0

High-throughput

0.458

High

787028

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

787031

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

787062

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.458

High

787091

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

787104

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.458

High

285603

BAF
Barrier-to-autointegration factor

1

3

High-throughput

0.457

High

133963

IPO5
Importin-5

1

7

High-throughput

0.437

High

159543

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.437

High

214180

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

2

High-throughput

0.437

High

220875

XPOT
Exportin-T

1

10

High-throughput

0.437

High

238415

RAD21
Double-strand-break repair protein rad21 homolog

1

2

High-throughput

0.437

High

244327

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

1

High-throughput

0.437

High

277582

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.437

High

280140

SC22B
Vesicle-trafficking protein SEC22b

1

5

High-throughput

0.437

High

290470

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.437

High

291235

NU155
Nuclear pore complex protein Nup155

1

6

High-throughput

0.437

High

338062

NSA2
Ribosome biogenesis protein NSA2 homolog

1

2

High-throughput

0.437

High

426220

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

4

High-throughput

0.437

High

469016

SRPRA
Signal recognition particle receptor subunit alpha

1

5

High-throughput

0.437

High

483528

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

5

High-throughput

0.437

High

539523

PYGB
Glycogen phosphorylase, brain form

1

3

High-throughput

0.437

High

627604

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

5

High-throughput

0.437

High

786980

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

5

High-throughput

0.437

High

786989

DHB4
Peroxisomal multifunctional enzyme type 2

1

5

High-throughput

0.437

High

786992

PSA
Puromycin-sensitive aminopeptidase

1

1

High-throughput

0.437

High

786994

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.437

High

786997

EPIPL
Epiplakin

1

5

High-throughput

0.437

High

786998

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

4

High-throughput

0.437

High

787000

ERF1
Eukaryotic peptide chain release factor subunit 1

1

3

High-throughput

0.437

High

787002

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.437

High

787004

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.437

High

787007

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

5

High-throughput

0.437

High

787014

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.437

High

787015

PWP1
Periodic tryptophan protein 1 homolog

1

7

High-throughput

0.437

High

787016

FHL3
Four and a half LIM domains protein 3

1

9

High-throughput

0.437

High

787020

CND2
Condensin complex subunit 2

1

3

High-throughput

0.437

High

787026

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.437

High

787029

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

13

High-throughput

0.437

High

787032

NU188
Nucleoporin NUP188

1

2

High-throughput

0.437

High

787037

NIPBL
Nipped-B-like protein

1

8

High-throughput

0.437

High

787040

TRM1L
tRNA

1

2

High-throughput

0.437

High

787041

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.437

High

787043

PHF6
PHD finger protein 6

1

5

High-throughput

0.437

High

787046

TAF1L
Transcription initiation factor TFIID subunit 1-like

1

3

High-throughput

0.437

High

787047

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.437

High

787048

KRI1
Protein KRI1 homolog

1

7

High-throughput

0.437

High

787052

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.437

High

787054

IPO4
Importin-4

1

7

High-throughput

0.437

High

787056

ELYS
Protein ELYS

1

7

High-throughput

0.437

High

787057

GCN1
Stalled ribosome sensor GCN1

1

8

High-throughput

0.437

High

787058

NU205
Nuclear pore complex protein Nup205

1

7

High-throughput

0.437

High

787060

ARHG2
Rho guanine nucleotide exchange factor 2

1

18

High-throughput

0.437

High

787065

ZN512
Zinc finger protein 512

1

3

High-throughput

0.437

High

787066

RBM14
RNA-binding protein 14

1

7

High-throughput

0.437

High

787067

PURB
Transcriptional regulator protein Pur-beta

1

2

High-throughput

0.437

High

787069

STRBP
Spermatid perinuclear RNA-binding protein

1

3

High-throughput

0.437

High

787070

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

High-throughput

0.437

High

787072

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.437

High

787074

GNL3
Guanine nucleotide-binding protein-like 3

1

1

High-throughput

0.437

High

787080

XPO5
Exportin-5

1

10

High-throughput

0.437

High

787083

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.437

High

787084

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

12

High-throughput

0.437

High

787088

FANCI
Fanconi anemia group I protein

1

6

High-throughput

0.437

High

787089

RBM28
RNA-binding protein 28

1

1

High-throughput

0.437

High

787096

IPO11
Importin-11

1

3

High-throughput

0.437

High

787099

MRT4
mRNA turnover protein 4 homolog

1

4

High-throughput

0.437

High

787100

DIM1
Dimethyladenosine transferase

1

1

High-throughput

0.437

High

787105

SBDS
Ribosome maturation protein SBDS

1

1

High-throughput

0.437

High

787106

DOP1B
Protein DOP1B

1

1

High-throughput

0.437

High

787107

NOC2L
Nucleolar complex protein 2 homolog

1

2

High-throughput

0.437

High

787111

TNPO3
Transportin-3

1

14

High-throughput

0.437

High

787112

SRPRB
Signal recognition particle receptor subunit beta

1

19

High-throughput

0.437

High

787113

SAR1B
Small COPII coat GTPase SAR1B

1

16

High-throughput

0.437

High

787103

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.269

Low

787027

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.261

Low

786996

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.249

Low

787005

EXOSX
Exosome complex component 10

1

0

High-throughput

0.249

Low

787036

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.249

Low

787049

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.249

Low

787073

CHOLN
Protein cholesin

1

0

High-throughput

0.249

Low

787094

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.249

Low

787097

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025