HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 282
+	Hs
		641724 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		641756 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516364 U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Mm
		641996 U2AF2_MOUSE (1-475): 2.34e-94: 295: 99.79		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Hs
		1020321 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		1020353 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		1020265 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		1031344 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		1020249 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Xl
		1265032 ELAV2_XENLA (97-470): 8.39e-68: 223: 13.43		ELAV2_XENLA (10-92): 8.97e-24: 100: 25.00
+	Hs
		516484 ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		963526 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		TIAR_HUMAN (8-102): 5.22e-19: 87.5: 26.32
+	Hs
		680455 ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79		TIA1_HUMAN (12-190): 8.64e-19: 87.2: 12.02
+	Hs
		1020259 ELAV3_HUMAN (127-472): 9.26e-67: 220: 13.98		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		963985 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Mm
		936687 ELAV1_MOUSE (149-471): 9.51e-73: 234: 14.58		Q80ZW7_MOUSE (12-196): 5.94e-18: 84.5: 11.89
+	Mm
		857310 ELAV1_MOUSE (149-471): 9.51e-73: 234: 14.58		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Zm
		111724 K7TYT2_MAIZE (117-470): 6.03e-67: 223: 14.65		K7TYT2_MAIZE (1-97): 1.18e-18: 87.2: 24.49
+	Hs
		516518 RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Zm
		8143 A0A1D6ELH4_MAIZE (87-419): 6.02e-48: 176: 15.27		A0A1D6ELH4_MAIZE (12-99): 5.87e-17: 82.5: 20.46