Protein: TSN5
Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Gene: TSN5, TSPAN5
Organism: Homo sapiens
Interactions: 116
UniProt ID: P62079

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005788 - endoplasmic reticulum lumen
GO:0005886 - plasma membrane
GO:0019899 - enzyme binding
GO:0045747 - positive regulation of Notch signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161016

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

3

20

Small-scale

0.871

High

349402

TSN15
Tetraspanin-15

2

18

High-throughput

0.776

High

560962

GP1BB
Platelet glycoprotein Ib beta chain

3

6

High-throughput

0.667

High

912654

CTR2
Cationic amino acid transporter 2

3

8

High-throughput

0.667

High

967299

EFNB1
Ephrin-B1

3

3

High-throughput

0.667

High

967302

CD47
Leukocyte surface antigen CD47

3

1

High-throughput

0.667

High

967308

AT2B3
Plasma membrane calcium-transporting ATPase 3

3

13

High-throughput

0.667

High

967324

TM87A
Transmembrane protein 87A

3

4

High-throughput

0.667

High

967332

PIEZ1
Piezo-type mechanosensitive ion channel component 1

3

2

High-throughput

0.667

High

967349

NDC1
Nucleoporin NDC1

3

1

High-throughput

0.667

High

967357

RDH14
Retinol dehydrogenase 14

3

5

High-throughput

0.667

High

967361

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

3

16

High-throughput

0.667

High

967326

DGLB
Diacylglycerol lipase-beta

3

5

High-throughput

0.650

High

582375

B4GT1
Beta-1,4-galactosyltransferase 1

3

0

High-throughput

0.638

High

967338

THA11
THAP domain-containing protein 11

3

0

High-throughput

0.638

High

967344

S38A2
Sodium-coupled neutral amino acid symporter 2

2

8

High-throughput

0.628

High

641933

CD9
CD9 antigen

1

20

High-throughput

0.625

High

873767

CD151
CD151 antigen

1

18

High-throughput

0.625

High

295914

SC5D
Lathosterol oxidase

3

5

High-throughput

0.609

High

773849

SOAT1
Sterol O-acyltransferase 1

3

2

High-throughput

0.609

High

967309

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

3

5

High-throughput

0.609

High

967313

LCLT1
Lysocardiolipin acyltransferase 1

3

16

High-throughput

0.609

High

967314

RETR3
Reticulophagy regulator 3

3

7

High-throughput

0.609

High

967321

NAT8L
N-acetylaspartate synthetase

3

1

High-throughput

0.609

High

967322

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.609

High

967328

RDH11
Retinol dehydrogenase 11

3

5

High-throughput

0.609

High

967330

NAT14
Probable N-acetyltransferase 14

3

1

High-throughput

0.609

High

967336

TM186
Transmembrane protein 186

3

4

High-throughput

0.609

High

967337

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

3

2

High-throughput

0.609

High

967339

TV23C
Golgi apparatus membrane protein TVP23 homolog C

3

2

High-throughput

0.609

High

967340

BSCL2
Seipin

3

4

High-throughput

0.609

High

967341

F210B
Protein FAM210B, mitochondrial

3

7

High-throughput

0.609

High

967343

RDH12
Retinol dehydrogenase 12

3

5

High-throughput

0.609

High

967353

SNX25
Sorting nexin-25

3

8

High-throughput

0.609

High

967354

ZDHC6
Palmitoyltransferase ZDHHC6

3

14

High-throughput

0.609

High

967356

WDR41
WD repeat-containing protein 41

3

1

High-throughput

0.609

High

967368

ZDHC9
Palmitoyltransferase ZDHHC9

3

10

High-throughput

0.609

High

329052

KLHL2
Kelch-like protein 2

3

2

High-throughput

0.599

High

298987

TSN9
Tetraspanin-9

1

19

High-throughput

0.575

High

845582

MUC18
Cell surface glycoprotein MUC18

1

13

High-throughput

0.575

High

898369

BCAM
Basal cell adhesion molecule

1

14

High-throughput

0.575

High

948746

CD81
CD81 antigen

1

19

High-throughput

0.575

High

967327

TSN14
Tetraspanin-14

1

18

High-throughput

0.575

High

967334

IGSF8
Immunoglobulin superfamily member 8

1

20

High-throughput

0.575

High

967347

PXL2A
Peroxiredoxin-like 2A

2

1

High-throughput

0.574

High

257618

PRAF2
PRA1 family protein 2

2

5

High-throughput

0.558

High

967319

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

2

6

High-throughput

0.558

High

967320

GHDC
GH3 domain-containing protein

2

5

High-throughput

0.558

High

967331

BRI3B
BRI3-binding protein

2

2

High-throughput

0.558

High

967360

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

16

High-throughput

0.558

High

967369

SPCS1
Signal peptidase complex subunit 1

2

1

High-throughput

0.558

High

723679

NTR1
Neurotensin receptor type 1

1

9

High-throughput

0.536

High

889958

PSN1
Presenilin-1

1

1

High-throughput

0.536

High

967305

KEAP1
Kelch-like ECH-associated protein 1

1

2

High-throughput

0.536

High

967315

ZDH21
Palmitoyltransferase ZDHHC21

1

14

High-throughput

0.536

High

967317

AN13A
Ankyrin repeat domain-containing protein 13A

1

2

High-throughput

0.536

High

967329

S20A1
Sodium-dependent phosphate transporter 1

1

1

High-throughput

0.536

High

967352

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.536

High

967358

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

3

High-throughput

0.536

High

269850

IGSF3
Immunoglobulin superfamily member 3

1

20

High-throughput

0.514

High

967365

FPRP
Prostaglandin F2 receptor negative regulator

1

20

High-throughput

0.514

High

421855

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

967300

KDSR
3-ketodihydrosphingosine reductase

1

12

High-throughput

0.489

High

967311

KLH17
Kelch-like protein 17

1

2

High-throughput

0.489

High

967323

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.489

High

967333

SNX19
Sorting nexin-19

1

6

High-throughput

0.489

High

967345

PIGS
GPI-anchor transamidase component PIGS

1

2

High-throughput

0.489

High

683592

ITA3
Integrin alpha-3

1

20

High-throughput

0.484

High

171433

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.479

High

184154

RER1
Protein RER1

1

1

High-throughput

0.479

High

890719

PSN2
Presenilin-2

1

1

High-throughput

0.479

High

967316

TM192
Transmembrane protein 192

1

3

High-throughput

0.479

High

967318

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

3

Small-scale

0.479

High

967348

TMM43
Transmembrane protein 43

1

2

High-throughput

0.479

High

277627

H2AY
Core histone macro-H2A.1

1

0

Small-scale

0.458

High

967355

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.458

High

230298

CREB3
Cyclic AMP-responsive element-binding protein 3

1

6

High-throughput

0.457

High

338603

AGRL2
Adhesion G protein-coupled receptor L2

1

13

High-throughput

0.445

High

376492

LDLR
Low-density lipoprotein receptor

1

3

High-throughput

0.445

High

390523

TFR1
Transferrin receptor protein 1

1

7

High-throughput

0.445

High

420468

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

10

High-throughput

0.445

High

431774

ITB1
Integrin beta-1

1

19

High-throughput

0.445

High

467439

4F2
Amino acid transporter heavy chain SLC3A2

1

4

High-throughput

0.445

High

484097

PGFRB
Platelet-derived growth factor receptor beta

1

8

High-throughput

0.445

High

591267

CD44
CD44 antigen

1

3

High-throughput

0.445

High

603768

ITA2
Integrin alpha-2

1

20

High-throughput

0.445

High

654954

ITA6
Integrin alpha-6

1

20

High-throughput

0.445

High

690223

STOM
Stomatin

1

3

High-throughput

0.445

High

878013

AGRE5
Adhesion G protein-coupled receptor E5

1

14

High-throughput

0.445

High

931333

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

7

High-throughput

0.445

High

967298

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

20

High-throughput

0.445

High

967301

CKAP4
Cytoskeleton-associated protein 4

1

8

High-throughput

0.445

High

967303

STX4
Syntaxin-4

1

12

High-throughput

0.445

High

967304

CD166
CD166 antigen

1

15

High-throughput

0.445

High

967307

S39AE
Metal cation symporter ZIP14

1

8

High-throughput

0.445

High

967310

SDK2
Protein sidekick-2

1

7

High-throughput

0.445

High

967312

CSPG4
Chondroitin sulfate proteoglycan 4

1

6

High-throughput

0.445

High

967359

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

967362

TEN2
Teneurin-2

1

8

High-throughput

0.445

High

967364

TEN3
Teneurin-3

1

8

High-throughput

0.445

High

178929

SCAM2
Secretory carrier-associated membrane protein 2

1

6

High-throughput

0.437

High

359964

NB5R3
NADH-cytochrome b5 reductase 3

1

4

High-throughput

0.437

High

506588

GPHRB
Golgi pH regulator B

1

4

High-throughput

0.437

High

967325

LEMD2
LEM domain-containing protein 2

1

2

High-throughput

0.437

High

967335

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.437

High

967351

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

2

High-throughput

0.437

High

94304

D6R9G5
Kelch like family member 2

1

3

High-throughput

0.407

High

967366

MRC2
C-type mannose receptor 2

1

8

High-throughput

0.407

High

967342

IMP1L
Mitochondrial inner membrane protease subunit 1

3

0

High-throughput

0.347

High

967363

TM248
Transmembrane protein 248

3

0

High-throughput

0.347

High

967367

MRM2
rRNA methyltransferase 2, mitochondrial

3

0

High-throughput

0.347

High

967306

SPCS2
Signal peptidase complex subunit 2

2

0

High-throughput

0.318

High

967346

SEC62
Translocation protein SEC62

2

0

High-throughput

0.318

High

967350

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

2

0

High-throughput

0.318

High

883461

DHE4
Glutamate dehydrogenase 2, mitochondrial

1

0

High-throughput

0.279

Low

967297

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025