HitPredict

Interactor 1: CNTF (P26441)
Ciliary neurotrophic factor (CNTF)
Gene: CNTF

Interactor 2: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	7810882, 7539796, 18775332, 20584990
Identification Methods	pull down, affinity chromatography technology, isothermal titration calorimetry, molecular sieving, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0043524 - negative regulation of neuron apoptotic process GO:0070120 - ciliary neurotrophic factor-mediated signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 200 Hs			1 372
+	Mm
		291718 CNTF_MOUSE (1-195): 1.16e-129: 364: 83.08		CNTFR_MOUSE (1-355): 8.43e-69: 222: 96.06
+	Hs
		642881 CNTF_HUMAN (1-200): 1.3e-137: 384: 100.00		LIFR_HUMAN (31-329): 2.83e-54: 194: 15.02
+	Hs
		445716 CNTF_HUMAN (1-200): 1.3e-137: 384: 100.00		IL6RA_HUMAN (22-363): 1.99e-56: 193: 25.00
+	Mm
		789689 CNTF_MOUSE (1-195): 1.16e-129: 364: 83.08		LIFR_MOUSE (19-329): 1.14e-52: 190: 16.51
+	Hs
		642879 CNTF_HUMAN (1-200): 1.3e-137: 384: 100.00		IL6RB_HUMAN (55-302): 3e-12: 70.2: 14.17
+	Mm
		848811 CNTF_MOUSE (1-195): 1.16e-129: 364: 83.08		IL6RB_MOUSE (65-302): 4.69e-11: 66.3: 14.74