Protein: NGAP
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)

Gene: NGAP, RASAL2
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q9UJF2

Gene Ontology (top 5):
GO:0002021 - response to dietary excess
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0009749 - response to glucose

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

711426

SHC1
SHC-transforming protein 1

2

20

High-throughput

0.811

High

1219097

DAB2P
Disabled homolog 2-interacting protein

2

14

High-throughput

0.789

High

1400175

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

13

High-throughput

0.776

High

376073

RASK
GTPase KRas

2

20

High-throughput

0.754

High

978387

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

966994

1433G
14-3-3 protein gamma

6

20

High-throughput

0.735

High

730336

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.730

High

877035

KC1A
Casein kinase I isoform alpha

5

5

High-throughput

0.725

High

691521

1433T
14-3-3 protein theta

4

20

High-throughput

0.699

High

1049888

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

659629

CRCM
Colorectal mutant cancer protein

4

7

High-throughput

0.692

High

885919

KC1E
Casein kinase I isoform epsilon

3

16

High-throughput

0.675

High

990845

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

126864

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

269630

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

6

High-throughput

0.618

High

374268

RASN
GTPase NRas

1

20

High-throughput

0.618

High

375002

RASH
GTPase HRas

1

20

High-throughput

0.618

High

440238

LCK
Tyrosine-protein kinase Lck

1

19

High-throughput

0.618

High

463829

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

466517

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581365

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601488

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

637970

NF1
Neurofibromin

1

14

High-throughput

0.618

High

901660

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.618

High

902135

RAB9A
Ras-related protein Rab-9A

1

11

High-throughput

0.618

High

910246

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953749

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955734

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956536

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.618

High

962616

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962853

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

976645

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

988808

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015894

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1145162

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

1151924

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1216104

SPD2A
SH3 and PX domain-containing protein 2A

1

8

High-throughput

0.618

High

1271043

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1366907

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1396652

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1433569

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1438231

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1460600

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.618

High

972106

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.611

High

1151505

IKBB
NF-kappa-B inhibitor beta

2

11

High-throughput

0.611

High

877256

KC1D
Casein kinase I isoform delta

2

10

High-throughput

0.601

High

226254

STX6
Syntaxin-6

1

0

High-throughput

0.586

High

347397

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.576

High

1093992

TRAF1
TNF receptor-associated factor 1

1

4

High-throughput

0.573

High

1384291

SH3K1
SH3 domain-containing kinase-binding protein 1

2

12

High-throughput

0.571

High

189917

STX7
Syntaxin-7

1

1

High-throughput

0.553

High

341164

DIRA3
GTP-binding protein Di-Ras3

1

11

High-throughput

0.553

High

845847

MUC18
Cell surface glycoprotein MUC18

1

7

High-throughput

0.553

High

1004233

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.553

High

215955

SYNJ1
Synaptojanin-1

1

2

High-throughput

0.541

High

931152

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

1279998

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

17

High-throughput

0.536

High

1330112

USBP1
Harmonin-binding protein USHBP1

1

7

High-throughput

0.523

High

508798

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

157965

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

208751

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

6

High-throughput

0.479

High

252187

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

281449

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.479

High

323595

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

High-throughput

0.479

High

339116

NADK
NAD kinase

1

1

High-throughput

0.479

High

404527

GCR
Glucocorticoid receptor

1

8

High-throughput

0.479

High

540741

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.479

High

541745

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

583013

EZRI
Ezrin

1

6

High-throughput

0.479

High

604262

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

605840

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.479

High

715836

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

719276

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

719383

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

730945

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

891348

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.479

High

891867

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

936478

AFAD
Afadin

1

20

High-throughput

0.479

High

941081

HDAC4
Histone deacetylase 4

1

5

High-throughput

0.479

High

975305

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

1025603

CDK16
Cyclin-dependent kinase 16

1

5

High-throughput

0.479

High

1045886

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1065780

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

10

High-throughput

0.479

High

1092511

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

7

High-throughput

0.479

High

1107314

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1141004

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1187598

AR13B
ADP-ribosylation factor-like protein 13B

1

9

High-throughput

0.479

High

1216034

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.479

High

1219635

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

1235011

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.479

High

1251464

GGYF2
GRB10-interacting GYF protein 2

1

12

High-throughput

0.479

High

1257052

SYDE1
Rho GTPase-activating protein SYDE1

1

9

High-throughput

0.479

High

1286556

PHLB2
Pleckstrin homology-like domain family B member 2

1

11

High-throughput

0.479

High

1309261

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.479

High

1323036

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

1349482

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1352620

DEN1A
DENN domain-containing protein 1A

1

8

High-throughput

0.479

High

1353299

PARD3
Partitioning defective 3 homolog

1

19

High-throughput

0.479

High

1396856

SNX27
Sorting nexin-27

1

14

High-throughput

0.479

High

1401133

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

1409798

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1412890

RTKN
Rhotekin

1

1

High-throughput

0.479

High

1432996

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1439695

MYO10
Unconventional myosin-X

1

10

Small-scale

0.479

High

1447277

KI13B
Kinesin-like protein KIF13B

1

7

High-throughput

0.479

High

1447411

ANLN
Anillin

1

4

High-throughput

0.479

High

1448703

LATS2
Serine/threonine-protein kinase LATS2

1

7

High-throughput

0.479

High

1448824

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

5

High-throughput

0.479

High

1459743

LIMA1
LIM domain and actin-binding protein 1

1

9

High-throughput

0.479

High

1460596

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.479

High

1460597

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1460598

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1460599

ALK
ALK tyrosine kinase receptor

1

17

High-throughput

0.479

High

1460601

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1232631

Q6FHY5
MEOX2 protein

1

4

High-throughput

0.470

High

1399556

MIA2
Melanoma inhibitory activity protein 2

1

11

High-throughput

0.470

High

481407

HMGB1
High mobility group protein B1

1

4

Small-scale

0.464

High

538078

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.445

High

1402922

CK5P2
CDK5 regulatory subunit-associated protein 2

1

13

High-throughput

0.445

High

894236

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.439

High

106820

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

176891

DCLK1
Serine/threonine-protein kinase DCLK1

1

17

High-throughput

0.437

High

230587

KIF1C
Kinesin-like protein KIF1C

1

7

High-throughput

0.437

High

245284

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

8

High-throughput

0.437

High

299421

FLOT1
Flotillin-1

1

6

High-throughput

0.437

High

373439

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

643127

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

710554

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.437

High

769461

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1041359

CAV1
Caveolin-1

1

6

High-throughput

0.437

High

1134080

ZN638
Zinc finger protein 638

1

3

High-throughput

0.437

High

1147460

EPHA7
Ephrin type-A receptor 7

1

16

High-throughput

0.437

High

1159897

OCLN
Occludin

1

2

High-throughput

0.437

High

1229125

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.437

High

1229908

AN34A
Ankyrin repeat domain-containing protein 34A

1

14

High-throughput

0.437

High

1233558

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.437

High

1256011

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1256629

CE128
Centrosomal protein of 128 kDa

1

11

High-throughput

0.437

High

1293249

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.437

High

1360413

SRS12
Serine/arginine-rich splicing factor 12

1

8

High-throughput

0.437

High

1381996

CK052
Uncharacterized protein C11orf52

1

4

High-throughput

0.437

High

1398235

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.437

High

1402225

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.437

High

1410857

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.437

High

1439415

E41LA
Band 4.1-like protein 4A

1

7

High-throughput

0.437

High

1452549

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1454246

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.437

High

1454711

CING
Cingulin

1

8

High-throughput

0.437

High

1460602

KCTD3
BTB/POZ domain-containing protein KCTD3

1

8

High-throughput

0.437

High

255271

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

1258613

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.407

High

140025

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

327495

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

693124

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.249

Low

880737

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1293195

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025