HitPredict

Interactor 1: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30083275
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_3~S_100
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 404
+	Hs
		615216 S10A1_HUMAN (1-90): 7.9e-37: 121: 51.11		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Rn
		385826 S100B_RAT (3-91): 1.34e-30: 105: 48.32		RAGE_RAT (1-404): 1.03e-73: 237: 77.97
+	Hs
		638960 S100P_HUMAN (3-96): 6.88e-35: 116: 41.49		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		380779 S100B_HUMAN (3-91): 3.86e-31: 106: 47.19		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		946195 S10AC_HUMAN (3-87): 4.08e-28: 99.1: 35.29		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		793247 S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		642975 S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		661374 S10A2_HUMAN (1-97): 1.08e-35: 118: 60.83		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42
+	Hs
		639033 S100P_HUMAN (3-96): 6.88e-35: 116: 41.49		PXDN_HUMAN (172-403): 7.12e-25: 109: 13.42