Protein: NU214
Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)

Gene: NU214, NUP214
Organism: Homo sapiens
Interactions: 180
UniProt ID: P35658

Gene Ontology (top 5):
GO:0005049 - nuclear export signal receptor activity
GO:0005635 - nuclear envelope
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

172516

XPO1
Exportin-1

5

20

Small-scale

0.918

High

775617

DD19B
ATP-dependent RNA helicase DDX19B

3

11

Small-scale

0.877

High

775537

IMB1
Importin subunit beta-1

3

20

Small-scale

0.861

High

775610

DD19A
ATP-dependent RNA helicase DDX19A

3

11

High-throughput

0.861

High

775612

NXF1
Nuclear RNA export factor 1

11

8

Small-scale

0.756

High

775592

NUP88
Nuclear pore complex protein Nup88

9

2

Small-scale

0.752

High

775490

NUP62
Nuclear pore glycoprotein p62

6

20

Small-scale

0.730

High

775517

RAN
GTP-binding nuclear protein Ran

4

7

Small-scale

0.699

High

775618

G3BP2
Ras GTPase-activating protein-binding protein 2

4

6

High-throughput

0.699

High

775513

NU107
Nuclear pore complex protein Nup107

4

8

Small-scale

0.686

High

775520

RAE1L
mRNA export factor RAE1

4

20

Small-scale

0.686

High

775598

NXF2
Nuclear RNA export factor 2

3

8

Small-scale

0.670

High

775504

RBP2
E3 SUMO-protein ligase RanBP2

3

9

Small-scale

0.656

High

775507

NUP98
Nuclear pore complex protein Nup98-Nup96

3

19

Small-scale

0.656

High

775534

CUL3
Cullin-3

3

8

High-throughput

0.656

High

775575

NUP35
Nucleoporin NUP35

3

5

Small-scale

0.640

High

775506

FXR2
RNA-binding protein FXR2

2

18

High-throughput

0.628

High

775529

G3BP1
Ras GTPase-activating protein-binding protein 1

2

7

High-throughput

0.628

High

775509

XPO2
Exportin-2

1

17

Small-scale

0.618

High

775585

TNPO1
Transportin-1

1

20

Small-scale

0.618

High

775603

XPO5
Exportin-5

1

17

Small-scale

0.618

High

775626

TNPO3
Transportin-3

1

20

Small-scale

0.618

High

775503

NU153
Nuclear pore complex protein Nup153

2

20

Small-scale

0.611

High

775553

NU188
Nucleoporin NUP188

2

1

Small-scale

0.611

High

775570

NUP93
Nuclear pore complex protein Nup93

2

5

Small-scale

0.611

High

775595

NUP58
Nucleoporin p58/p45

2

15

Small-scale

0.611

High

133960

IPO5
Importin-5

2

19

Small-scale

0.595

High

240917

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

291231

NU155
Nuclear pore complex protein Nup155

2

9

Small-scale

0.584

High

775493

CCNF
Cyclin-F

2

6

High-throughput

0.584

High

775512

HDAC4
Histone deacetylase 4

2

20

Small-scale

0.584

High

775552

GLE1
mRNA export factor GLE1

2

14

Small-scale

0.584

High

775596

NUP85
Nuclear pore complex protein Nup85

2

6

Small-scale

0.584

High

775619

DICER
Endoribonuclease Dicer

1

6

Small-scale

0.575

High

775627

EMIL1
EMILIN-1

2

8

High-throughput

0.574

High

688222

TTP
mRNA decay activator protein ZFP36

1

2

Small-scale

0.573

High

775545

ITSN1
Intersectin-1

2

17

High-throughput

0.571

High

775551

PKHG6
Pleckstrin homology domain-containing family G member 6

2

8

High-throughput

0.571

High

775625

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

2

8

High-throughput

0.571

High

775522

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.561

High

775530

SMAD4
Mothers against decapentaplegic homolog 4

1

6

Small-scale

0.561

High

775543

SMAD2
Mothers against decapentaplegic homolog 2

1

5

Small-scale

0.561

High

668520

APC
Adenomatous polyposis coli protein

1

14

High-throughput

0.541

High

185480

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

12

High-throughput

0.536

High

539961

BCR
Breakpoint cluster region protein

1

12

High-throughput

0.536

High

720955

CLIP1
CAP-Gly domain-containing linker protein 1

1

9

High-throughput

0.536

High

775496

TEC
Tyrosine-protein kinase Tec

1

13

High-throughput

0.536

High

775497

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.536

High

775498

RANG
Ran-specific GTPase-activating protein

1

13

High-throughput

0.536

High

775500

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

775501

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

775518

UBC9
SUMO-conjugating enzyme UBC9

1

5

High-throughput

0.536

High

775519

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.536

High

775533

CUL2
Cullin-2

1

8

High-throughput

0.536

High

775536

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.536

High

775538

NUMA1
Nuclear mitotic apparatus protein 1

1

7

High-throughput

0.536

High

775542

MARE1
Microtubule-associated protein RP/EB family member 1

1

6

High-throughput

0.536

High

775576

UHMK1
Serine/threonine-protein kinase Kist

1

4

High-throughput

0.536

High

775578

NEK7
Serine/threonine-protein kinase Nek7

1

8

High-throughput

0.536

High

775582

DNJC9
DnaJ homolog subfamily C member 9

1

4

High-throughput

0.536

High

775587

SEH1
Nucleoporin SEH1

1

20

High-throughput

0.536

High

775589

AURKB
Aurora kinase B

1

9

High-throughput

0.536

High

775594

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

6

High-throughput

0.536

High

775604

NXT2
NTF2-related export protein 2

1

7

High-throughput

0.536

High

775608

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.536

High

775621

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

775623

CLC11
C-type lectin domain family 11 member A

2

2

High-throughput

0.521

High

775489

NU214
Nuclear pore complex protein Nup214

1

16

Small-scale

0.501

High

775514

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.501

High

775593

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.501

High

424486

PAI2
Plasminogen activator inhibitor 2

1

1

High-throughput

0.489

High

775590

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

775591

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

775628

RPKL1
Ribosomal protein S6 kinase-like 1

1

8

High-throughput

0.489

High

58707

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

5

High-throughput

0.479

High

138638

IMA4
Importin subunit alpha-4

1

9

Small-scale

0.479

High

159541

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

High-throughput

0.479

High

228555

STRN
Striatin

1

20

Small-scale

0.479

High

246453

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

247242

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

7

High-throughput

0.479

High

247707

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

271945

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

371332

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.479

High

385508

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

14

High-throughput

0.479

High

552763

TPR
Nucleoprotein TPR

1

16

Small-scale

0.479

High

588056

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.479

High

606335

CEBPB
CCAAT/enhancer-binding protein beta

1

15

High-throughput

0.479

High

633409

MX2
Interferon-induced GTP-binding protein Mx2

1

6

Small-scale

0.479

High

694771

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

731018

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

764485

CTNB1
Catenin beta-1

1

16

High-throughput

0.479

High

767552

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

775491

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

775492

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.479

High

775494

ETV6
Transcription factor ETV6

1

11

High-throughput

0.479

High

775495

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.479

High

775499

RAGP1
Ran GTPase-activating protein 1

1

3

Small-scale

0.479

High

775502

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

775505

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

775508

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.479

High

775510

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

775511

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

11

Small-scale

0.479

High

775515

NTF2
Nuclear transport factor 2

1

7

High-throughput

0.479

High

775516

H4
Histone H4

1

6

High-throughput

0.479

High

775524

KMT2A
Histone-lysine N-methyltransferase 2A

1

14

Small-scale

0.479

High

775525

TF65
Transcription factor p65

1

15

High-throughput

0.479

High

775526

NU160
Nuclear pore complex protein Nup160

1

3

Small-scale

0.479

High

775528

RFA4
Replication protein A 30 kDa subunit

1

10

High-throughput

0.479

High

775531

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

775532

HDAC1
Histone deacetylase 1

1

17

High-throughput

0.479

High

775535

CUL4B
Cullin-4B

1

8

High-throughput

0.479

High

775539

CUL7
Cullin-7

1

8

High-throughput

0.479

High

775541

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

775544

SMAD1
Mothers against decapentaplegic homolog 1

1

5

Small-scale

0.479

High

775547

EZH2
Histone-lysine N-methyltransferase EZH2

1

14

High-throughput

0.479

High

775548

E2F4
Transcription factor E2F4

1

6

High-throughput

0.479

High

775549

IF16
Gamma-interferon-inducible protein 16

1

6

High-throughput

0.479

High

775550

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

775559

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

775562

NUP54
Nucleoporin p54

1

18

Small-scale

0.479

High

775564

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

14

High-throughput

0.479

High

775565

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

775566

NAA40
N-alpha-acetyltransferase 40

1

7

High-throughput

0.479

High

775567

TAXB1
Tax1-binding protein 1

1

8

High-throughput

0.479

High

775568

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

775569

SLX4
Structure-specific endonuclease subunit SLX4

1

11

High-throughput

0.479

High

775571

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

775572

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

775573

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

775574

NUP37
Nucleoporin Nup37

1

17

Small-scale

0.479

High

775581

NU133
Nuclear pore complex protein Nup133

1

5

Small-scale

0.479

High

775583

NU205
Nuclear pore complex protein Nup205

1

8

Small-scale

0.479

High

775584

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

775586

PF21A
PHD finger protein 21A

1

13

High-throughput

0.479

High

775588

RNF31
E3 ubiquitin-protein ligase RNF31

1

12

High-throughput

0.479

High

775602

RANB3
Ran-binding protein 3

1

13

Small-scale

0.479

High

775605

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

775606

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

775607

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

775611

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

Small-scale

0.479

High

775613

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

775615

HDAC9
Histone deacetylase 9

1

20

Small-scale

0.479

High

775616

NUP50
Nuclear pore complex protein Nup50

1

12

Small-scale

0.479

High

775620

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.479

High

775624

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

192556

NUP42
Nucleoporin NUP42

1

0

Small-scale

0.460

High

213449

CTIF
CBP80/20-dependent translation initiation factor

1

0

High-throughput

0.458

High

775523

SET
Protein SET

1

0

Small-scale

0.458

High

775527

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

775555

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

775580

PO210
Nuclear pore membrane glycoprotein 210

1

0

Small-scale

0.458

High

775597

NDEL1
Nuclear distribution protein nudE-like 1

1

13

High-throughput

0.457

High

664843

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

1

High-throughput

0.445

High

775577

S7A14
Solute carrier family 7 member 14

1

1

High-throughput

0.445

High

775599

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

11

High-throughput

0.445

High

775600

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

11

High-throughput

0.445

High

293298

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

411481

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.437

High

555914

CADH1
Cadherin-1

1

1

High-throughput

0.437

High

565196

ITA4
Integrin alpha-4

1

4

High-throughput

0.437

High

642669

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

775540

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

Small-scale

0.437

High

775554

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.437

High

775556

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

775558

DPPA3
Developmental pluripotency-associated protein 3

1

1

High-throughput

0.437

High

775560

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

775561

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

775563

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

13

High-throughput

0.437

High

775579

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.437

High

775601

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

775622

T3JAM
TRAF3-interacting JNK-activating modulator

1

9

Small-scale

0.437

High

166259

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.407

High

619556

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.407

High

775521

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

775546

UT2
Urea transporter 2

1

1

High-throughput

0.407

High

775609

S39A9
Zinc transporter ZIP9

1

1

High-throughput

0.407

High

775614

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

775557

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.265

Low

379225

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025