HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: TIE2 (Q02858)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
Gene: Tek

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.808

The method score is based on:

Property Details
Experiments 10521483, 9632797
Identification Methods two hybrid, pull down, affinity chromatography technology
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0016020 - membrane
GO:0042307 - positive regulation of protein import into nucleus
GO:0043066 - negative regulation of apoptotic process
GO:0048471 - perinuclear region of cytoplasm
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 724
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Last updated: 15 Jul 2024