Protein: IF2A
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)

Gene: IF2A, EIF2S1
Organism: Homo sapiens
Interactions: 215
UniProt ID: P05198

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005850 - eukaryotic translation initiation factor 2 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

398639

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

10

6

Small-scale

0.979

High

398664

IF2G
Eukaryotic translation initiation factor 2 subunit 3

8

9

Small-scale

0.965

High

398634

KPCA
Protein kinase C alpha type

2

1

Small-scale

0.768

High

398657

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

1

High-throughput

0.737

High

398685

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.735

High

398640

IF2B
Eukaryotic translation initiation factor 2 subunit 2

6

6

Small-scale

0.733

High

213881

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

2

High-throughput

0.691

High

398632

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

3

High-throughput

0.691

High

398642

MAK
Serine/threonine-protein kinase MAK

1

4

High-throughput

0.691

High

398735

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.691

High

275363

PR15A
Protein phosphatase 1 regulatory subunit 15A

4

1

Small-scale

0.683

High

398767

ANM7
Protein arginine N-methyltransferase 7

4

0

Small-scale

0.673

High

398705

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

Small-scale

0.647

High

398753

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

12

Small-scale

0.647

High

398770

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

15

Small-scale

0.647

High

230833

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.618

High

148279

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.618

High

398709

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.618

High

398756

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.618

High

398693

VAC14
Protein VAC14 homolog

2

2

High-throughput

0.606

High

398625

TAU
Microtubule-associated protein tau

3

0

High-throughput

0.597

High

127983

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.586

High

398663

CCNF
Cyclin-F

2

0

High-throughput

0.585

High

133837

DDX3X
ATP-dependent RNA helicase DDX3X

2

3

Small-scale

0.585

High

226255

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

243787

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

398633

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

398645

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.584

High

398628

ACTN1
Alpha-actinin-1

2

0

High-throughput

0.580

High

330811

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.575

High

373510

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.575

High

398714

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

368810

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

345680

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

398757

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

398638

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

398650

1433S
14-3-3 protein sigma

1

0

Small-scale

0.537

High

275779

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

2

High-throughput

0.536

High

336302

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

398658

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

398673

IF5
Eukaryotic translation initiation factor 5

1

6

High-throughput

0.536

High

398675

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

4

High-throughput

0.536

High

398676

IF4A1
Eukaryotic initiation factor 4A-I

1

2

High-throughput

0.536

High

398679

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

398683

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.536

High

398687

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.536

High

398730

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

398732

DDX60
Probable ATP-dependent RNA helicase DDX60

1

5

High-throughput

0.536

High

398738

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

398742

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

398755

RBM42
RNA-binding protein 42

1

3

High-throughput

0.536

High

398781

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

398782

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

398655

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

398778

HECD1
E3 ubiquitin-protein ligase HECTD1

2

2

Small-scale

0.533

High

388150

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

239477

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.515

High

128400

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

283353

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

380230

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

398619

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

398622

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

398630

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

398644

HMGB2
High mobility group protein B2

1

0

High-throughput

0.513

High

398666

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

398668

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

398670

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

398671

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

398775

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

398785

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

398617

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.501

High

398678

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.501

High

398776

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

398691

TIE2
Angiopoietin-1 receptor

1

6

High-throughput

0.489

High

398711

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.480

High

122441

MEN1
Menin

1

1

High-throughput

0.479

High

125084

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

162335

XPO1
Exportin-1

1

4

High-throughput

0.479

High

168705

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

5

Small-scale

0.479

High

232760

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

282474

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

294259

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

322068

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

383525

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.479

High

398618

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.479

High

398620

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.479

High

398621

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

7

High-throughput

0.479

High

398624

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

398626

ERG
Transcriptional regulator ERG

1

1

Small-scale

0.479

High

398627

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.479

High

398629

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

398635

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

398646

EPHB2
Ephrin type-B receptor 2

1

2

High-throughput

0.479

High

398647

LTK
Leukocyte tyrosine kinase receptor

1

9

High-throughput

0.479

High

398648

UFO
Tyrosine-protein kinase receptor UFO

1

8

High-throughput

0.479

High

398651

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

398656

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

398659

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

398661

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

398662

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

398665

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

398672

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

3

High-throughput

0.479

High

398674

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

398677

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

398686

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

3

Small-scale

0.479

High

398694

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

398697

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

6

High-throughput

0.479

High

398698

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

398700

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

398701

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

398703

CUL3
Cullin-3

1

1

High-throughput

0.479

High

398704

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

398706

RBM39
RNA-binding protein 39

1

2

High-throughput

0.479

High

398707

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

6

High-throughput

0.479

High

398708

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.479

High

398710

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

398718

CDC73
Parafibromin

1

1

High-throughput

0.479

High

398719

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

398721

LMTK1
Serine/threonine-protein kinase LMTK1

1

10

High-throughput

0.479

High

398722

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

398726

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

398727

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

398729

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.479

High

398731

LMTK2
Serine/threonine-protein kinase LMTK2

1

9

High-throughput

0.479

High

398736

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

398740

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

398741

RENT1
Regulator of nonsense transcripts 1

1

1

Small-scale

0.479

High

398743

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

398747

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

398751

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

398752

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.479

High

398758

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

398760

DDX24
ATP-dependent RNA helicase DDX24

1

12

High-throughput

0.479

High

398764

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

398766

ANLN
Anillin

1

1

High-throughput

0.479

High

398772

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

398774

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

398777

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

398779

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

398780

ALK
ALK tyrosine kinase receptor

1

9

High-throughput

0.479

High

398784

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

398786

MAFB
Transcription factor MafB

1

2

High-throughput

0.479

High

398787

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.479

High

153974

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

119083

LEG9
Galectin-9

1

0

High-throughput

0.458

High

155242

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

169363

BET1
BET1 homolog

1

0

High-throughput

0.458

High

224268

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

233141

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

298049

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

302778

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

309768

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.458

High

362675

FINC
Fibronectin

1

0

High-throughput

0.458

High

398616

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

398623

FURIN
Furin

1

0

High-throughput

0.458

High

398631

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

398636

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.458

High

398641

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

398652

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

398654

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

398680

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

398681

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

398682

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.458

High

398684

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

398689

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

398699

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

398712

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

398713

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

398724

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

398725

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

398728

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

398733

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

398734

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

398739

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

398744

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

398745

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

398746

TRI11
E3 ubiquitin-protein ligase TRIM11

1

0

Small-scale

0.458

High

398750

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

398754

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

398759

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

398761

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

398763

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

398765

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

398768

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

398769

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

398771

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

398773

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

398615

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

398653

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

398702

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

398717

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

384087

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

398637

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.437

High

398643

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.437

High

398660

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.437

High

398688

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

398690

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

10

High-throughput

0.437

High

398692

RON
Macrophage-stimulating protein receptor

1

6

High-throughput

0.437

High

398696

MERTK
Tyrosine-protein kinase Mer

1

7

High-throughput

0.437

High

398715

OTUD1
OTU domain-containing protein 1

1

1

High-throughput

0.437

High

398716

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

398723

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

398749

LMTK3
Serine/threonine-protein kinase LMTK3

1

11

High-throughput

0.437

High

398762

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

398695

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

398669

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

71377

B2Y833
TMPRSS2-ERG prostate cancer specific isoform 1

1

1

Small-scale

0.407

High

376131

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

398649

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

398748

RILP
Rab-interacting lysosomal protein

1

0

High-throughput

0.279

Low

225463

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

398667

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

398720

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

398737

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.249

Low

398783

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024