HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: EPS8 (Q08509)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12515821
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 821
+	Mm
		643068 P85A_MOUSE (1-724): 0: 566: 100.00		CRKL_MOUSE (506-703): 3.76e-40: 151: 18.45
+	Mm
		643099 P85A_MOUSE (1-724): 0: 566: 100.00		CRK_MOUSE (394-701): 9.8e-39: 148: 11.00
+	Hs
		655266 P85A_HUMAN (1-724): 0: 556: 94.35		CRKL_HUMAN (506-703): 2.12e-39: 150: 17.96
+	Hs
		655265 P85A_HUMAN (1-724): 0: 556: 94.35		CRK_HUMAN (394-701): 8.81e-39: 148: 11.00
+	Mm
		643066 P85A_MOUSE (1-724): 0: 566: 100.00		FYN_MOUSE (455-593): 4.01e-30: 127: 16.31
+	Hs
		433263 P85A_HUMAN (1-724): 0: 556: 94.35		YES_HUMAN (449-593): 5.21e-31: 130: 20.00
+	Hs
		412033 P85A_HUMAN (1-724): 0: 556: 94.35		FYN_HUMAN (455-593): 1.72e-30: 128: 16.31
+	Mm
		643064 P85A_MOUSE (1-724): 0: 566: 100.00		BTK_MOUSE (490-588): 7.9e-24: 109: 16.98
+	Hs
		655277 P85A_HUMAN (1-724): 0: 556: 94.35		BLK_HUMAN (495-591): 7.42e-25: 111: 23.47
+	Hs
		655386 P85A_HUMAN (1-724): 0: 556: 94.35		ITSN1_HUMAN (401-760): 8.92e-24: 110: 9.39
+	Hs
		557615 P85A_HUMAN (1-724): 0: 556: 94.35		NCK1_HUMAN (487-737): 7.13e-22: 100: 9.73
+	Mm
		557349 P85A_MOUSE (1-724): 0: 566: 100.00		BLK_MOUSE (492-594): 1.54e-10: 66.5: 21.15
+	Mm
		140063 P85B_MOUSE (3-723): 3.36e-157: 474: 56.77		CRK_MOUSE (394-701): 9.8e-39: 148: 11.00
+	Hs
		129238 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		CRKL_HUMAN (506-703): 2.12e-39: 150: 17.96
+	Hs
		129237 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		CRK_HUMAN (394-701): 8.81e-39: 148: 11.00
+	Hs
		129164 P85B_HUMAN (4-719): 5.61e-156: 471: 57.10		FYN_HUMAN (455-593): 1.72e-30: 128: 16.31
+	Hs
		802683 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		CRK_HUMAN (394-701): 8.81e-39: 148: 11.00
+	Hs
		433433 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		YES_HUMAN (449-593): 5.21e-31: 130: 20.00
+	Hs
		412285 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		FYN_HUMAN (455-593): 1.72e-30: 128: 16.31
+	Hs
		557757 P55G_HUMAN (271-723): 6.47e-94: 301: 72.31		NCK1_HUMAN (487-737): 7.13e-22: 100: 9.73