HitPredict

Interactor 1: NKG2A (P26715)
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Gene: KLRC1

Interactor 2: FCGRN (P55899)
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Gene: FCGRT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0009897 - external side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 233 Hs			1 365
+	Hs
		354302 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HLAB_HUMAN (1-357): 1.03e-136: 395: 26.63
+	Hs
		570305 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HLAG_HUMAN (1-307): 6.38e-133: 384: 27.36
+	Hs
		59726 KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		533124 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HLAE_HUMAN (20-310): 1.29e-124: 364: 29.14
+	Hs
		533125 NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68		HLAE_HUMAN (20-310): 1.29e-124: 364: 29.14
+	Hs
		382559 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		382561 CLC4A_HUMAN (34-231): 2.26e-41: 142: 16.81		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		644616 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HMR1_HUMAN (8-347): 3.27e-113: 334: 28.53
+	Hs
		644688 NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68		HMR1_HUMAN (8-347): 3.27e-113: 334: 28.53
+	Hs
		354602 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAB_HUMAN (1-357): 1.03e-136: 395: 26.63
+	Hs
		59727 KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		354435 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		HLAB_HUMAN (1-357): 1.03e-136: 395: 26.63
+	Hs
		488420 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		488205 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		488421 CLC4A_HUMAN (34-231): 2.26e-41: 142: 16.81		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		533144 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		HLAE_HUMAN (20-310): 1.29e-124: 364: 29.14
+	Hs
		673960 CL12B_HUMAN (113-231): 1.89e-44: 151: 31.01		HLAF_HUMAN (4-343): 2.87e-120: 352: 28.81
+	Hs
		674000 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAF_HUMAN (4-343): 2.87e-120: 352: 28.81
+	Hs
		673995 CLC2D_HUMAN (51-231): 6.82e-43: 145: 21.28		HLAF_HUMAN (4-343): 2.87e-120: 352: 28.81
+	Hs
		1278673 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HMR1_HUMAN (8-347): 3.27e-113: 334: 28.53