Protein: PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]

Gene: PUR2, GART
Organism: Homo sapiens
Interactions: 153
UniProt ID: P22102

Gene Ontology (top 5):
GO:0003360 - brainstem development
GO:0004637 - phosphoribosylamine-glycine ligase activity
GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644 - phosphoribosylglycinamide formyltransferase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

644466

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

2

7

High-throughput

0.754

High

644546

INP5K
Inositol polyphosphate 5-phosphatase K

4

0

High-throughput

0.667

High

240751

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

644557

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.618

High

644505

CUL3
Cullin-3

2

1

High-throughput

0.611

High

644487

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.575

High

644510

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

644485

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

0

High-throughput

0.559

High

644518

ARHGI
Rho guanine nucleotide exchange factor 18

2

0

High-throughput

0.559

High

530994

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.547

High

644527

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

529079

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.536

High

644474

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

644483

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

644533

CUL5
Cullin-5

1

1

High-throughput

0.536

High

644543

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.536

High

644577

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

644478

PAXI
Paxillin

1

0

High-throughput

0.518

High

644491

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.515

High

644524

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

3

High-throughput

0.515

High

213809

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

389029

FINC
Fibronectin

1

0

High-throughput

0.513

High

644492

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.513

High

644498

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

644499

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

644520

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

644538

MYO19
Unconventional myosin-XIX

1

0

High-throughput

0.513

High

644560

RTN4
Reticulon-4

1

0

High-throughput

0.513

High

644570

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.513

High

185425

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

644488

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

644575

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.480

High

348364

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

408674

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.479

High

644469

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

644471

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

644486

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

644490

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

644494

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

644497

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.479

High

644500

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

644501

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

644507

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

644508

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

644532

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

644535

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

644536

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

644544

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

644548

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

644551

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

644552

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.479

High

644555

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

644561

ANLN
Anillin

1

1

High-throughput

0.479

High

644562

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

644568

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

644569

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

644576

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

352964

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

644482

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

125229

LEG9
Galectin-9

1

0

High-throughput

0.458

High

156958

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

176025

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.458

High

271896

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

315115

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319396

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345370

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

349796

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

402523

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

411352

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

413188

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

445736

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

536497

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

565556

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.458

High

578634

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

644480

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

644481

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

644484

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

644489

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

644495

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

644496

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.458

High

644502

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

644503

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

644504

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

644506

CUL7
Cullin-7

1

0

High-throughput

0.458

High

644509

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

644512

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

644513

KIF19
Kinesin-like protein KIF19

1

0

High-throughput

0.458

High

644514

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

644515

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

644517

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

644522

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

644529

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

644534

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

644539

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

0

Small-scale

0.458

High

644540

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

644542

NECD
Necdin

1

0

High-throughput

0.458

High

644554

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

644559

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

644563

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

644566

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

644567

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

644571

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

644578

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.458

High

644468

GRN
Progranulin

1

1

High-throughput

0.445

High

644553

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

644556

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

105339

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

644475

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.437

High

644519

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

644521

KCTD9
BTB/POZ domain-containing protein KCTD9

1

1

High-throughput

0.437

High

644523

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

3

High-throughput

0.437

High

644550

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.437

High

644558

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

174185

SYN3
Synapsin-3

1

0

High-throughput

0.426

High

563195

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

619491

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

644476

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

644537

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

644564

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

429303

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

644545

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

484379

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

644470

CNR2
Cannabinoid receptor 2

1

0

Small-scale

0.279

Low

644473

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

644477

NEST
Nestin

1

0

High-throughput

0.279

Low

644511

DREB
Drebrin

1

0

High-throughput

0.279

Low

644516

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

644549

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

642615

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.269

Low

247677

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

257335

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

259442

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

371165

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

376707

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.249

Low

587915

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

590802

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

606222

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

644467

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

644472

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

644479

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

644525

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

644526

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

644528

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

644531

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

644541

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

644547

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

644565

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

644572

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

644573

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

644574

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

644493

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low

644530

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025