HitPredict

Interactor 1: NKG2A (P26715)
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Gene: KLRC1

Interactor 2: B2MG (P61769)
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Gene: B2M

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18448674, 18083576
Identification Methods	x-ray crystallography, surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 233 Hs			1 119
+	Hs
		354302 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HLAB_HUMAN (2-117): 7.05e-44: 148: 19.66
+	Hs
		570305 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HLAG_HUMAN (2-116): 6.98e-44: 147: 22.41
+	Hs
		533124 NKG2A_HUMAN (1-233): 3.96e-72: 221: 100.00		HLAE_HUMAN (3-117): 8.23e-41: 140: 22.03
+	Hs
		533125 NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68		HLAE_HUMAN (3-117): 8.23e-41: 140: 22.03
+	Hs
		644670 NKG2C_HUMAN (1-233): 3.88e-72: 221: 74.68		B2MG_HUMAN (1-119): 1.69e-42: 137: 100.00
+	Hs
		656362 NKG2E_HUMAN (1-225): 2.84e-67: 209: 69.03		DMB_HUMAN (16-119): 1.43e-36: 126: 27.36
+	Hs
		59726 KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05		HLAA_HUMAN (2-116): 6.86e-47: 155: 22.41
+	Hs
		59727 KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05		HLAC_HUMAN (2-117): 4.98e-46: 153: 19.66
+	Hs
		382559 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAA_HUMAN (2-116): 6.86e-47: 155: 22.41
+	Hs
		673960 CL12B_HUMAN (113-231): 1.89e-44: 151: 31.01		HLAF_HUMAN (2-116): 3.24e-45: 151: 25.00
+	Hs
		488420 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAC_HUMAN (2-117): 4.98e-46: 153: 19.66
+	Hs
		488205 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		HLAC_HUMAN (2-117): 4.98e-46: 153: 19.66
+	Hs
		674000 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAF_HUMAN (2-116): 3.24e-45: 151: 25.00
+	Hs
		59733 KLRG2_HUMAN (75-231): 3.26e-45: 157: 24.05		DPA1_HUMAN (19-118): 1.53e-41: 139: 34.65
+	Hs
		354602 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		HLAB_HUMAN (2-117): 7.05e-44: 148: 19.66
+	Hs
		354435 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		HLAB_HUMAN (2-117): 7.05e-44: 148: 19.66
+	Hs
		533144 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		HLAE_HUMAN (3-117): 8.23e-41: 140: 22.03
+	Hs
		945195 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		DRB3_HUMAN (25-115): 2.56e-41: 139: 33.70
+	Hs
		355004 CLC4E_HUMAN (51-231): 2.31e-43: 147: 16.51		DRB1_HUMAN (11-115): 6.84e-41: 137: 32.08
+	Hs
		901866 KLRD1_HUMAN (69-233): 1.35e-43: 146: 32.35		B2MG_HUMAN (1-119): 1.69e-42: 137: 100.00