HitPredict

Interactor 1: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 217
+	Hs
		924809 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		770716 CSF3R_MOUSE (2-346): 2.16e-57: 202: 19.37		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		500956 GHR_HUMAN (110-300): 2.28e-42: 158: 18.54		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		411919 CSF3R_MOUSE (2-346): 2.16e-57: 202: 19.37		LCK_MOUSE (3-202): 2.89e-37: 137: 28.44
+	Hs
		557612 CNTFR_HUMAN (1-356): 8.9e-69: 222: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337354 CNTFR_HUMAN (1-356): 8.9e-69: 222: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		817315 LEPR_HUMAN (190-301): 5.62e-15: 78.8: 23.68		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		412029 CNTFR_HUMAN (1-356): 8.9e-69: 222: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		442875 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433961 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		435879 CSF3R_MOUSE (2-346): 2.16e-57: 202: 19.37		HCK_MOUSE (119-215): 2.26e-11: 64.2: 23.23
+	Hs
		548629 PRLR_HUMAN (106-324): 1.04e-51: 183: 21.68		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		500941 GHR_HUMAN (110-300): 2.28e-42: 158: 18.54		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		560471 PRLR_HUMAN (106-324): 1.04e-51: 183: 21.68		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		235234 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		235231 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		235232 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		411613 UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		412016 PTPRD_HUMAN (58-341): 1.32e-15: 80.7: 10.10		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522808 UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58