HitPredict

Interactor 1: CRBB3 (P26998)
Beta-crystallin B3 (Beta-B3 crystallin) [Cleaved into: Beta-crystallin B3, N-terminally processed]
Gene: CRYBB3

Interactor 2: CRBA2 (P53672)
Beta-crystallin A2 (Beta-A2 crystallin)
Gene: CRYBA2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	17662718
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Crystall~Crystall
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005212 - structural constituent of eye lens GO:0007601 - visual perception
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 211 Hs			1 197
+	Hs
		409338 CRBB3_HUMAN (1-211): 6.64e-114: 325: 100.00		CRBA1_HUMAN (5-197): 1.12e-91: 268: 53.61
+	Bt
		359284 CRBB3_BOVIN (1-211): 2.14e-113: 324: 91.00		CRBB2_BOVIN (2-196): 3.23e-74: 224: 39.29
+	Hs
		409340 CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56		CRBA1_HUMAN (5-197): 1.12e-91: 268: 53.61
+	Hs
		795390 CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56		CRBA2_HUMAN (14-197): 8.31e-90: 263: 100.00
+	Hs
		795391 CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56		CRBA4_HUMAN (1-197): 5.89e-89: 261: 52.28
+	Hs
		409337 CRBA1_HUMAN (22-199): 1.97e-77: 233: 43.62		CRBA1_HUMAN (5-197): 1.12e-91: 268: 53.61
+	Mm
		914858 CRBB2_MOUSE (1-211): 4.41e-91: 267: 55.19		CRBB2_MOUSE (2-196): 1.35e-73: 222: 38.78
+	Hs
		863882 CRBA4_HUMAN (21-199): 1.82e-75: 227: 41.27		CRBA4_HUMAN (1-197): 5.89e-89: 261: 52.28
+	Bt
		359283 CRBB2_BOVIN (1-211): 1.6e-89: 263: 54.25		CRBB2_BOVIN (2-196): 3.23e-74: 224: 39.29
+	Hs
		795389 CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56		CRBB2_HUMAN (2-196): 1.04e-72: 220: 37.76
+	Hs
		409341 CRBA1_HUMAN (22-199): 1.97e-77: 233: 43.62		CRBB1_HUMAN (9-196): 1.33e-76: 231: 48.15
+	Hs
		863883 CRBA4_HUMAN (21-199): 1.82e-75: 227: 41.27		CRBB1_HUMAN (9-196): 1.33e-76: 231: 48.15
+	Hs
		863856 CRBA2_HUMAN (26-198): 7.21e-69: 210: 44.02		CRBB1_HUMAN (9-196): 1.33e-76: 231: 48.15
+	Hs
		645955 CRBB3_HUMAN (1-211): 6.64e-114: 325: 100.00		CRBB3_HUMAN (103-195): 3.55e-16: 75: 31.18
+	Hs
		426906 CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56		CRGC_HUMAN (7-99): 1.43e-22: 91.2: 30.11