HitPredict

Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: ACV1B (P36896)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: ACVR1B

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.912

The method score is based on:

Property Details
Experiments 30891432, 11927552, 9892009, 8612709, 9032295
Identification Methods affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~Activin_recp, Pkinase~Pkinase, Pkinase~TGF_beta_GS
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0007178 - cell surface receptor protein serine/threonine kinase signaling pathway
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 513
Hs

1 505
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Last updated: 15 Jul 2024