HitPredict

Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: RN149 (Q8NC42)
E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)
Gene: RNF149

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0046872 - metal ion binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 400
+	Hs
		1044928 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		738377 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		740013 TGFR2_HUMAN (28-493): 8.82e-123: 372: 33.79		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		1046378 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		738560 TGFR1_HUMAN (60-488): 5.17e-120: 363: 32.31		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		981128 ACVR1_HUMAN (47-493): 6.71e-117: 355: 30.27		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		738471 ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41		RN149_HUMAN (1-400): 4.22e-129: 378: 100.00
+	Hs
		738387 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		RN133_HUMAN (3-371): 1.3e-95: 292: 30.61
+	Hs
		738558 TGFR1_HUMAN (60-488): 5.17e-120: 363: 32.31		GOLI_HUMAN (30-374): 2.45e-84: 264: 40.52
+	Hs
		1044930 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		ZNRF4_HUMAN (32-389): 1.03e-53: 185: 18.35
+	Zm
		9118 A0A1D6EU89_MAIZE (199-492): 2.2e-25: 112: 28.90		B4FHZ7_MAIZE (227-370): 2.85e-27: 112: 27.78