Protein: ULK1
Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)

Gene: ULK1
Organism: Homo sapiens
Interactions: 182
UniProt ID: O75385

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000421 - autophagosome membrane
GO:0000423 - mitophagy
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

279156

SQSTM
Sequestosome-1

6

11

Small-scale

0.950

High

279151

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

4

17

Small-scale

0.908

High

279078

ULK1
Serine/threonine-protein kinase ULK1

3

19

Small-scale

0.855

High

279133

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

3

17

Small-scale

0.847

High

279238

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

18

Small-scale

0.802

High

279172

CDC37
Hsp90 co-chaperone Cdc37

2

10

Small-scale

0.789

High

271382

ATG13
Autophagy-related protein 13

28

5

Small-scale

0.769

High

279191

RBCC1
RB1-inducible coiled-coil protein 1

17

20

Small-scale

0.764

High

279212

ATGA1
Autophagy-related protein 101

9

4

Small-scale

0.755

High

279161

BECN1
Beclin-1

10

3

Small-scale

0.755

High

279099

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

279143

RAB1A
Ras-related protein Rab-1A

2

4

Small-scale

0.754

High

279206

NLRP3
NACHT, LRR and PYD domains-containing protein 3

2

2

Small-scale

0.754

High

279171

MK14
Mitogen-activated protein kinase 14

1

16

Small-scale

0.747

High

279088

GBRAP
Gamma-aminobutyric acid receptor-associated protein

7

13

Small-scale

0.746

High

279139

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

6

13

Small-scale

0.739

High

279219

MLP3B
Microtubule-associated protein 1 light chain 3 beta

6

13

Small-scale

0.731

High

279124

MTOR
Serine/threonine-protein kinase mTOR

6

13

Small-scale

0.730

High

279107

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

Small-scale

0.724

High

279234

ST38L
Serine/threonine-protein kinase 38-like

1

16

Small-scale

0.724

High

279216

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

5

13

Small-scale

0.716

High

279180

BAKOR
Beclin 1-associated autophagy-related key regulator

4

1

Small-scale

0.705

High

279205

CI072
Guanine nucleotide exchange factor C9orf72

5

3

Small-scale

0.700

High

279187

RPTOR
Regulatory-associated protein of mTOR

4

12

Small-scale

0.698

High

279208

NED4L
E3 ubiquitin-protein ligase NEDD4-like

4

19

Small-scale

0.692

High

279154

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.691

High

279199

SGK3
Serine/threonine-protein kinase Sgk3

1

19

High-throughput

0.691

High

279207

RBM14
RNA-binding protein 14

1

1

High-throughput

0.691

High

279223

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

4

13

Small-scale

0.689

High

279220

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

4

13

Small-scale

0.688

High

279218

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

3

5

Small-scale

0.667

High

279132

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

3

18

Small-scale

0.667

High

279239

TRAF6
TNF receptor-associated factor 6

3

18

Small-scale

0.662

High

279176

A16L1
Autophagy-related protein 16-1

3

15

Small-scale

0.656

High

214359

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

5

Small-scale

0.647

High

279096

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.646

High

279117

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.646

High

279137

SESN2
Sestrin-2

2

1

Small-scale

0.639

High

279183

ATG9A
Autophagy-related protein 9A

2

2

Small-scale

0.634

High

256559

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

7

High-throughput

0.618

High

193475

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.618

High

212626

DAPK3
Death-associated protein kinase 3

1

19

Small-scale

0.618

High

225504

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

19

High-throughput

0.618

High

279101

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

279110

RALB
Ras-related protein Ral-B

1

13

Small-scale

0.618

High

279118

DNJB2
DnaJ homolog subfamily B member 2

1

4

Small-scale

0.618

High

279138

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

Small-scale

0.618

High

279155

BIRC2
Baculoviral IAP repeat-containing protein 2

1

9

Small-scale

0.618

High

279168

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.618

High

279215

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

Small-scale

0.618

High

279231

TBK1
Serine/threonine-protein kinase TBK1

1

17

Small-scale

0.618

High

279241

CERT
Ceramide transfer protein

1

7

Small-scale

0.618

High

279119

MAP4
Microtubule-associated protein 4

2

20

Small-scale

0.611

High

279140

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

279189

FLCN
Folliculin

2

0

Small-scale

0.598

High

279152

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

14

Small-scale

0.595

High

279202

NRBF2
Nuclear receptor-binding factor 2

2

0

Small-scale

0.592

High

279192

SMCR8
Guanine nucleotide exchange protein SMCR8

2

1

Small-scale

0.586

High

279162

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.586

High

279236

KLH20
Kelch-like protein 20

1

6

Small-scale

0.586

High

279116

RO52
E3 ubiquitin-protein ligase TRIM21

2

8

Small-scale

0.584

High

279127

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

19

Small-scale

0.584

High

279111

TRI27
Zinc finger protein RFP

1

8

Small-scale

0.578

High

279198

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

9

Small-scale

0.578

High

279235

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

17

Small-scale

0.578

High

279095

MBP
Myelin basic protein

2

0

Small-scale

0.577

High

279209

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

15

Small-scale

0.573

High

279224

ZFYV1
Zinc finger FYVE domain-containing protein 1

2

2

Small-scale

0.571

High

194771

MEFV
Pyrin

1

7

Small-scale

0.561

High

279090

TRI16
Tripartite motif-containing protein 16

1

7

Small-scale

0.561

High

279091

STABP
STAM-binding protein

1

1

Small-scale

0.561

High

279125

HD
Huntingtin

1

8

Small-scale

0.554

High

140080

SDCB1
Syntenin-1

1

7

Small-scale

0.552

High

63807

PEDS1
Plasmanylethanolamine desaturase 1

1

0

Small-scale

0.537

High

279147

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.537

High

279186

EXOC8
Exocyst complex component 8

1

0

Small-scale

0.537

High

279089

RCBT2
RCC1 and BTB domain-containing protein 2

1

4

High-throughput

0.536

High

279094

CYTS
Cystatin-S

1

2

High-throughput

0.536

High

279100

TPM2
Tropomyosin beta chain

1

9

High-throughput

0.536

High

279102

CATG
Cathepsin G

1

4

High-throughput

0.536

High

279104

TPM1
Tropomyosin alpha-1 chain

1

10

High-throughput

0.536

High

279105

CLCB
Clathrin light chain B

1

2

High-throughput

0.536

High

279120

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.536

High

279128

GLYG
Glycogenin-1

1

1

High-throughput

0.536

High

279142

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.536

High

279144

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

279148

AKP13
A-kinase anchor protein 13

1

13

High-throughput

0.536

High

279165

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

8

High-throughput

0.536

High

279185

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

12

High-throughput

0.536

High

279221

ATG5
Autophagy protein 5

1

2

Small-scale

0.536

High

279240

ATG4B
Cysteine protease ATG4B

1

1

High-throughput

0.536

High

279081

HSBP1
Heat shock factor-binding protein 1

1

0

High-throughput

0.513

High

279135

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.513

High

279193

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

279233

JUPI1
Jupiter microtubule associated homolog 1

1

0

High-throughput

0.513

High

279141

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

Small-scale

0.508

High

279228

TBC14
TBC1 domain family member 14

1

3

Small-scale

0.506

High

135422

DNM1L
Dynamin-1-like protein

1

5

Small-scale

0.479

High

170581

CLGN
Calmegin

1

2

Small-scale

0.479

High

174866

SC16A
Protein transport protein Sec16A

1

3

Small-scale

0.479

High

279079

PSIP1
PC4 and SFRS1-interacting protein

1

2

High-throughput

0.479

High

279080

ERLN1
Erlin-1

1

1

Small-scale

0.479

High

279084

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

5

Small-scale

0.479

High

279085

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.479

High

279086

ERLN2
Erlin-2

1

4

Small-scale

0.479

High

279087

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

11

Small-scale

0.479

High

279093

LDHA
L-lactate dehydrogenase A chain

1

2

Small-scale

0.479

High

279097

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

279098

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

279103

VIME
Vimentin

1

6

Small-scale

0.479

High

279106

PARP1
Poly [ADP-ribose] polymerase 1

1

7

Small-scale

0.479

High

279112

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

279114

CXA1
Gap junction alpha-1 protein

1

7

Small-scale

0.479

High

279123

SRBP1
Sterol regulatory element-binding protein 1

1

3

Small-scale

0.479

High

279126

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

15

Small-scale

0.479

High

279129

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

4

Small-scale

0.479

High

279131

COPB
Coatomer subunit beta

1

4

Small-scale

0.479

High

279145

E2F1
Transcription factor E2F1

1

3

Small-scale

0.479

High

279149

TRI32
E3 ubiquitin-protein ligase TRIM32

1

9

Small-scale

0.479

High

279150

TRAF3
TNF receptor-associated factor 3

1

16

Small-scale

0.479

High

279157

CUL3
Cullin-3

1

12

Small-scale

0.479

High

279159

KEAP1
Kelch-like ECH-associated protein 1

1

7

Small-scale

0.479

High

279160

GAS6
Growth arrest-specific protein 6

1

2

High-throughput

0.479

High

279163

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.479

High

279164

LPIN1
Phosphatidate phosphatase LPIN1

1

2

Small-scale

0.479

High

279169

DHC24
Delta(24)-sterol reductase

1

2

Small-scale

0.479

High

279170

E2F4
Transcription factor E2F4

1

3

Small-scale

0.479

High

279174

RTN1
Reticulon-1

1

1

Small-scale

0.479

High

279175

ATG2A
Autophagy-related protein 2 homolog A

1

5

Small-scale

0.479

High

279177

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

1

Small-scale

0.479

High

279178

OTU7B
OTU domain-containing protein 7B

1

8

Small-scale

0.479

High

279181

VP13C
Intermembrane lipid transfer protein VPS13C

1

4

Small-scale

0.479

High

279190

WDR48
WD repeat-containing protein 48

1

8

Small-scale

0.479

High

279194

SL9A6
Sodium/hydrogen exchanger 6

1

2

Small-scale

0.479

High

279196

ESR2
Estrogen receptor beta

1

20

Small-scale

0.479

High

279197

BAD
Bcl2-associated agonist of cell death

1

2

Small-scale

0.479

High

279200

ATG2B
Autophagy-related protein 2 homolog B

1

5

Small-scale

0.479

High

279201

OPTN
Optineurin

1

20

High-throughput

0.479

High

279203

STALP
AMSH-like protease

1

1

Small-scale

0.479

High

279204

EXOC2
Exocyst complex component 2

1

1

Small-scale

0.479

High

279210

VP13A
Intermembrane lipid transfer protein VPS13A

1

4

Small-scale

0.479

High

279211

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.479

High

279213

LST8
Target of rapamycin complex subunit LST8

1

5

Small-scale

0.479

High

279217

OSBL6
Oxysterol-binding protein-related protein 6

1

6

Small-scale

0.479

High

279225

RTN4
Reticulon-4

1

1

Small-scale

0.479

High

279226

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.479

High

279229

HDAC6
Protein deacetylase HDAC6

1

17

Small-scale

0.479

High

279230

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

18

High-throughput

0.479

High

279232

NB5R1
NADH-cytochrome b5 reductase 1

1

1

Small-scale

0.479

High

279242

COPG1
Coatomer subunit gamma-1

1

3

Small-scale

0.479

High

279173

OCLN
Occludin

1

2

Small-scale

0.464

High

49985

IRGM
Immunity-related GTPase family M protein

1

0

Small-scale

0.458

High

211698

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

Small-scale

0.458

High

279082

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

Small-scale

0.458

High

279092

FADS2
Acyl-CoA 6-desaturase

1

0

Small-scale

0.458

High

279108

MGST1
Microsomal glutathione S-transferase 1

1

0

Small-scale

0.458

High

279109

CLUS
Clusterin

1

0

Small-scale

0.458

High

279121

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

0

Small-scale

0.458

High

279122

PGH2
Prostaglandin G/H synthase 2

1

0

Small-scale

0.458

High

279136

TMM33
Transmembrane protein 33

1

0

Small-scale

0.458

High

279146

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.458

High

279158

PTC1
Protein patched homolog 1

1

0

Small-scale

0.458

High

279166

JOS1
Josephin-1

1

0

Small-scale

0.458

High

279167

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

Small-scale

0.458

High

279184

DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

1

0

Small-scale

0.458

High

279214

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.458

High

279222

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

Small-scale

0.458

High

279153

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

Small-scale

0.445

High

279195

TBCD5
TBC1 domain family member 5

1

2

Small-scale

0.445

High

279227

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

279113

H2AX
Histone H2AX

1

4

Small-scale

0.437

High

276019

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.426

High

279237

WASC3
WASH complex subunit 3

2

0

High-throughput

0.328

High

64450

F221B
Protein FAM221B

1

0

High-throughput

0.279

Low

279083

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.279

Low

279115

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

279134

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.279

Low

279179

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

279182

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.279

Low

279188

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.279

Low

279130

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025