HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: SIK1 (P57059)
Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)
Gene: SIK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	36806887, 32707033, 36736316
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0071889 - 14-3-3 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 783
+	Hs
		883214 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SIK1_HUMAN (1-783): 0: 724: 100.00
+	Hs
		910013 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11
+	Xl
		223345 O57468_XENLA (2-243): 4.53e-144: 404: 64.75		Q8QGV3_XENLA (11-719): 4.86e-156: 475: 29.40
+	Hs
		909730 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61
+	Mm
		910234 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK2_MOUSE (5-716): 2.02e-153: 468: 29.53
+	Mm
		910231 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK3_MOUSE (18-634): 2.81e-152: 464: 32.08
+	Hs
		647862 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK3_HUMAN (18-634): 1.04e-151: 463: 31.60
+	Mm
		910318 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK1_MOUSE (15-704): 3.85e-148: 455: 29.35
+	Xl
		223344 O57468_XENLA (2-243): 4.53e-144: 404: 64.75		Q804T2_XENLA (18-610): 1.38e-149: 456: 33.22
+	Hs
		910106 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK1_HUMAN (15-704): 7.62e-148: 454: 29.21
+	Hs
		910187 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SIK3_HUMAN (11-760): 1.44e-142: 454: 30.33
+	Hs
		910071 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SNRK_HUMAN (25-438): 9.94e-148: 453: 36.94
+	Mm
		910308 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		MARK4_MOUSE (18-715): 4.24e-146: 448: 32.82
+	Hs
		909916 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MARK4_HUMAN (18-715): 3.07e-145: 446: 32.40
+	Dm
		90534 1433E_DROME (2-242): 6.77e-143: 401: 65.02		E1JGN0_DROME (7-676): 1.51e-141: 447: 29.40
+	Hs
		909507 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AAPK1_HUMAN (1-530): 1.08e-142: 433: 30.97
+	Hs
		871354 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AAPK2_HUMAN (13-523): 1.66e-142: 432: 31.41
+	Rn
		871214 1433E_RAT (2-243): 1.31e-144: 406: 63.53		AAPK1_RAT (1-530): 1.02e-141: 430: 30.78
+	At
		965360 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CIPKC_ARATH (4-376): 1.84e-139: 422: 29.87
+	At
		788672 14333_ARATH (3-243): 8e-143: 401: 61.63		CIPKC_ARATH (4-376): 1.84e-139: 422: 29.87