Protein: ANM6
Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6) (Histone-arginine N-methyltransferase PRMT6)

Gene: ANM6, PRMT6
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q96LA8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1396914

ANM6
Protein arginine N-methyltransferase 6

2

16

Small-scale

0.778

High

1086287

TFCP2
Alpha-globin transcription factor CP2

3

4

High-throughput

0.667

High

1089511

ILF2
Interleukin enhancer-binding factor 2

3

6

High-throughput

0.667

High

1368819

N42L2
NEDD4-binding protein 2-like 2

3

2

High-throughput

0.667

High

1396921

DDX23
Probable ATP-dependent RNA helicase DDX23

3

7

High-throughput

0.667

High

1396937

UBIP1
Upstream-binding protein 1

3

4

High-throughput

0.667

High

1396941

LEF1
Lymphoid enhancer-binding factor 1

3

2

High-throughput

0.662

High

1258918

H32
Histone H3.2

3

16

Small-scale

0.655

High

1119985

CIRBP
Cold-inducible RNA-binding protein

2

16

High-throughput

0.628

High

1396943

AKT3
RAC-gamma serine/threonine-protein kinase

2

2

High-throughput

0.628

High

601811

HMGA1
High mobility group protein HMG-I/HMG-Y

2

0

Small-scale

0.618

High

1396934

TF7L2
Transcription factor 7-like 2

2

2

High-throughput

0.612

High

186791

P73
Tumor protein p73

2

6

High-throughput

0.611

High

1331349

ENAH
Protein enabled homolog

3

3

High-throughput

0.609

High

1396942

DJC12
DnaJ homolog subfamily C member 12

3

2

High-throughput

0.609

High

1396954

S23IP
SEC23-interacting protein

3

5

High-throughput

0.609

High

980159

H4
Histone H4

2

8

Small-scale

0.602

High

244758

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.602

High

1201229

SPIN4
Spindlin-4

2

2

High-throughput

0.601

High

1363944

SMG7
Nonsense-mediated mRNA decay factor SMG7

2

0

High-throughput

0.585

High

1396932

KIF9
Kinesin-like protein KIF9

2

4

High-throughput

0.578

High

377835

IGF2
Insulin-like growth factor 2

2

0

High-throughput

0.576

High

128042

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.573

High

181924

SMAD9
Mothers against decapentaplegic homolog 9

1

5

High-throughput

0.573

High

897648

RASF2
Ras association domain-containing protein 2

1

1

High-throughput

0.573

High

1134839

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

18

High-throughput

0.573

High

1286254

PCGF5
Polycomb group RING finger protein 5

1

3

High-throughput

0.573

High

1352198

GRHL3
Grainyhead-like protein 3 homolog

1

4

High-throughput

0.573

High

1389866

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

High-throughput

0.573

High

1396938

HESX1
Homeobox expressed in ES cells 1

1

7

High-throughput

0.573

High

1396940

SRGEF
Secretion-regulating guanine nucleotide exchange factor

1

2

High-throughput

0.573

High

915477

HMGA2
High mobility group protein HMGI-C

1

1

Small-scale

0.561

High

160004

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.549

High

369199

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.549

High

1323659

THMS1
Protein THEMIS

1

0

High-throughput

0.549

High

1392612

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.549

High

1396923

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.549

High

1396927

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.549

High

1329268

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.549

High

170532

RAB7L
Ras-related protein Rab-7L1

1

1

High-throughput

0.536

High

931063

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

1023278

RBM3
RNA-binding protein 3

1

15

High-throughput

0.536

High

1089808

ILF3
Interleukin enhancer-binding factor 3

1

9

High-throughput

0.536

High

1231861

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

6

High-throughput

0.536

High

1259428

TBA1A
Tubulin alpha-1A chain

1

7

High-throughput

0.536

High

1396924

BEX2
Protein BEX2

1

1

High-throughput

0.536

High

1396933

BEX1
Protein BEX1

1

1

High-throughput

0.536

High

1396935

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

1

High-throughput

0.536

High

1384497

SPSB1
SPRY domain-containing SOCS box protein 1

1

15

High-throughput

0.523

High

1394827

LOXL4
Lysyl oxidase homolog 4

1

1

High-throughput

0.523

High

1396919

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

5

High-throughput

0.523

High

1396922

GTPB2
GTP-binding protein 2

1

4

High-throughput

0.523

High

1396945

KLH20
Kelch-like protein 20

1

2

High-throughput

0.523

High

832936

CETN2
Centrin-2

1

0

High-throughput

0.518

High

181409

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.513

High

946186

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

1317079

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

193864

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

4

High-throughput

0.508

High

298617

RAD17
Cell cycle checkpoint protein RAD17

1

2

High-throughput

0.508

High

335495

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.508

High

440681

FYN
Tyrosine-protein kinase Fyn

1

2

High-throughput

0.508

High

478336

HXC4
Homeobox protein Hox-C4

1

3

High-throughput

0.508

High

634870

HXA5
Homeobox protein Hox-A5

1

5

High-throughput

0.508

High

833161

MNDA
Myeloid cell nuclear differentiation antigen

1

4

High-throughput

0.508

High

885367

HXA1
Homeobox protein Hox-A1

1

6

High-throughput

0.508

High

938777

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

17

High-throughput

0.508

High

1036541

ID2
DNA-binding protein inhibitor ID-2

1

1

High-throughput

0.508

High

1239467

H3C
Histone H3.3C

1

16

High-throughput

0.508

High

1248064

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.508

High

1308770

NOSTN
Nostrin

1

4

High-throughput

0.508

High

1316763

WDFY3
WD repeat and FYVE domain-containing protein 3

1

7

High-throughput

0.508

High

1363533

TRIB2
Tribbles homolog 2

1

4

High-throughput

0.508

High

1364967

TSC1
Hamartin

1

4

High-throughput

0.508

High

1392032

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

High-throughput

0.508

High

1396917

LENG8
Leukocyte receptor cluster member 8

1

6

High-throughput

0.508

High

1396925

LDH6B
L-lactate dehydrogenase A-like 6B

1

6

High-throughput

0.508

High

1396926

ZN436
Zinc finger protein 436

1

1

High-throughput

0.508

High

1396936

DCA16
DDB1- and CUL4-associated factor 16

1

1

High-throughput

0.508

High

1396939

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

1

High-throughput

0.508

High

1396948

PYGO1
Pygopus homolog 1

1

5

High-throughput

0.508

High

1396949

MTF2
Metal-response element-binding transcription factor 2

1

2

High-throughput

0.508

High

1396951

SPIN1
Spindlin-1

1

2

High-throughput

0.508

High

550418

PABP1
Polyadenylate-binding protein 1

1

8

Small-scale

0.501

High

643988

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

8

Small-scale

0.501

High

1163144

H2B2E
Histone H2B type 2-E

1

9

High-throughput

0.501

High

1232712

H2A2A
Histone H2A type 2-A

1

5

High-throughput

0.501

High

1191938

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.489

High

1279017

TAFA3
Chemokine-like protein TAFA-3

1

1

High-throughput

0.489

High

1396931

LRC40
Leucine-rich repeat-containing protein 40

1

1

High-throughput

0.489

High

1396953

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

6

High-throughput

0.489

High

216518

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.486

High

305847

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.486

High

988614

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.486

High

1211610

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.486

High

1396928

GO45
Golgin-45

1

0

High-throughput

0.486

High

1396944

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.486

High

1331733

ZN557
Zinc finger protein 557

1

2

High-throughput

0.481

High

1098585

GPS2
G protein pathway suppressor 2

1

0

Small-scale

0.480

High

260317

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

325053

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

584133

FOSL2
Fos-related antigen 2

1

3

High-throughput

0.479

High

937854

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

1091140

FOXC1
Forkhead box protein C1

1

4

High-throughput

0.479

High

1212834

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.479

High

1334790

SERB1
SERPINE1 mRNA-binding protein 1

1

7

High-throughput

0.479

High

69860

A8K932
Kinesin-like protein

1

4

High-throughput

0.470

High

142392

PEX7
Peroxisomal targeting signal 2 receptor

1

8

High-throughput

0.464

High

212781

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

3

High-throughput

0.464

High

451240

NFL
Neurofilament light polypeptide

1

9

High-throughput

0.464

High

554278

BMP3
Bone morphogenetic protein 3

1

1

High-throughput

0.464

High

931204

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

1

High-throughput

0.464

High

1046667

GLGB
1,4-alpha-glucan-branching enzyme

1

1

High-throughput

0.464

High

1199939

P5CR3
Pyrroline-5-carboxylate reductase 3

1

1

High-throughput

0.464

High

1396950

ASB3
Ankyrin repeat and SOCS box protein 3

1

1

High-throughput

0.464

High

1396930

AUNIP
Aurora kinase A- and ninein-interacting protein

1

0

High-throughput

0.460

High

297669

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.445

High

911056

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.445

High

1229224

ZNF57
Zinc finger protein 57

1

0

High-throughput

0.438

High

106480

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1227272

A16L1
Autophagy-related protein 16-1

1

9

Small-scale

0.437

High

351346

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.426

High

1165389

Q17RG0
Autophagy-related protein 16-1

1

9

High-throughput

0.407

High

1387927

RM38
Large ribosomal subunit protein mL38

3

0

High-throughput

0.351

High

1109114

PPR1A
Protein phosphatase 1 regulatory subunit 1A

3

0

High-throughput

0.347

High

1394672

KIRR1
Kin of IRRE-like protein 1

3

0

High-throughput

0.347

High

1248572

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1396918

SOST
Sclerostin

2

0

High-throughput

0.328

High

1360613

MADD
MAP kinase-activating death domain protein

2

0

High-throughput

0.318

High

1240282

CH074
Uncharacterized protein C8orf74

1

0

High-throughput

0.299

High

1337367

GSTCD
Glutathione S-transferase C-terminal domain-containing protein

1

0

High-throughput

0.299

High

1396946

STA10
START domain-containing protein 10

1

0

High-throughput

0.299

High

1396947

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.299

High

1312810

NRM
Nurim

1

0

High-throughput

0.279

Low

1322264

FCSK
L-fucose kinase

1

0

High-throughput

0.279

Low

1336545

MROH1
Maestro heat-like repeat-containing protein family member 1

1

0

High-throughput

0.279

Low

281502

FBX24
F-box only protein 24

1

0

Small-scale

0.269

Low

295759

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.265

Low

877753

T23O
Tryptophan 2,3-dioxygenase

1

0

High-throughput

0.265

Low

1139905

MLC1
Membrane protein MLC1

1

0

High-throughput

0.265

Low

1256458

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.265

Low

1293446

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.265

Low

1340593

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.265

Low

1396915

UBX10
UBX domain-containing protein 10

1

0

High-throughput

0.265

Low

1396916

KAD8
Adenylate kinase 8

1

0

High-throughput

0.265

Low

1396920

PELO
Protein pelota homolog

1

0

High-throughput

0.265

Low

1396929

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.265

Low

1396952

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.265

Low

565684

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.249

Low

1350244

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

1

0

High-throughput

0.249

Low

1104

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1108885

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025