HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	16943424, 20086099
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding GO:0032991 - protein-containing complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 491
+	Hs
		926930 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Mm
		620839 1433T_MOUSE (1-245): 2.96e-141: 397: 99.59		MDM2_MOUSE (1-490): 0: 639: 80.24
+	Hs
		683969 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		169269 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169241 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169273 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169244 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169245 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169280 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		169266 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Mm
		193158 1433G_MOUSE (1-242): 5.48e-105: 305: 70.33		MDM4_MOUSE (4-489): 0: 522: 32.36