HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1591
+	Hs
		909501 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Mm
		910228 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		ARG28_MOUSE (645-1544): 1.35e-118: 413: 13.84
+	Mm
		926776 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARG28_MOUSE (645-1544): 1.35e-118: 413: 13.84
+	Hs
		909803 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARG28_HUMAN (647-1544): 9.69e-115: 402: 13.10
+	Hs
		647099 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ARG28_HUMAN (647-1544): 9.69e-115: 402: 13.10
+	Hs
		909491 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AKP13_HUMAN (646-1590): 1.94e-104: 373: 13.83
+	Hs
		646842 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		AKP13_HUMAN (646-1590): 1.94e-104: 373: 13.83
+	Hs
		909883 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG2_HUMAN (821-1575): 9.12e-97: 338: 13.13
+	Hs
		909551 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG7_HUMAN (818-1568): 7.77e-97: 333: 14.38
+	Hs
		647169 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ARHG2_HUMAN (821-1575): 9.12e-97: 338: 13.13
+	Mm
		926797 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG2_MOUSE (821-1576): 9.13e-94: 329: 12.90
+	Hs
		909921 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SPT13_HUMAN (801-1473): 7.06e-90: 309: 17.13
+	Hs
		647196 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SPT13_HUMAN (801-1473): 7.06e-90: 309: 17.13
+	Mm
		926851 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG6_MOUSE (815-1591): 1.5e-86: 303: 15.76
+	Hs
		909717 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		FGD6_HUMAN (764-1451): 2.66e-80: 294: 16.11
+	Hs
		50576 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PKHG3_HUMAN (984-1587): 7.98e-80: 291: 17.03
+	Hs
		910068 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG4_HUMAN (992-1459): 3.98e-82: 287: 19.96
+	Hs
		647028 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		FGD6_HUMAN (764-1451): 2.66e-80: 294: 16.11
+	Hs
		50558 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PKHG3_HUMAN (984-1587): 7.98e-80: 291: 17.03
+	Mm
		926883 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG7_MOUSE (991-1446): 4.46e-61: 228: 18.18