Protein: CRY2
Cryptochrome-2

Gene: CRY2
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q49AN0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0003684 - damaged DNA binding
GO:0003677 - DNA binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176204

PER2
Period circadian protein homolog 2

5

20

Small-scale

0.922

High

1157647

CRY1
Cryptochrome-1

4

7

Small-scale

0.892

High

193784

PER1
Period circadian protein homolog 1

3

20

High-throughput

0.849

High

1193529

CRY2
Cryptochrome-2

2

7

Small-scale

0.767

High

1193577

FBXL3
F-box/LRR-repeat protein 3

7

7

Small-scale

0.751

High

885797

KC1E
Casein kinase I isoform epsilon

4

8

Small-scale

0.702

High

877132

KC1D
Casein kinase I isoform delta

4

8

High-throughput

0.697

High

942030

PER3
Period circadian protein homolog 3

1

20

High-throughput

0.691

High

1193530

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

1

High-throughput

0.675

High

1144764

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.667

High

1193547

TEKT4
Tektin-4

3

1

High-throughput

0.667

High

1193555

AP2M1
AP-2 complex subunit mu

3

1

High-throughput

0.667

High

1193578

TIM
Protein timeless homolog

1

2

Small-scale

0.665

High

992200

SKP1
S-phase kinase-associated protein 1

3

1

Small-scale

0.662

High

303333

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3

0

High-throughput

0.646

High

1103204

CTBP1
C-terminal-binding protein 1

2

1

High-throughput

0.628

High

1193565

XRN2
5'-3' exoribonuclease 2

3

0

High-throughput

0.625

High

916665

PPP5
Serine/threonine-protein phosphatase 5

2

7

Small-scale

0.614

High

685857

KRA59
Keratin-associated protein 5-9

2

8

High-throughput

0.606

High

950263

KR107
Keratin-associated protein 10-7

2

7

High-throughput

0.606

High

950499

KR108
Keratin-associated protein 10-8

2

7

High-throughput

0.606

High

1059643

KRA11
Keratin-associated protein 1-1

2

7

High-throughput

0.606

High

1090683

TRAF2
TNF receptor-associated factor 2

2

2

High-throughput

0.606

High

1093836

TRAF1
TNF receptor-associated factor 1

2

2

High-throughput

0.606

High

1193536

KRA57
Keratin-associated protein 5-7

2

8

High-throughput

0.606

High

1193537

KRA54
Keratin-associated protein 5-4

2

6

High-throughput

0.606

High

1193539

KRA51
Keratin-associated protein 5-1

2

1

High-throughput

0.606

High

1193545

KRA13
Keratin-associated protein 1-3

2

7

High-throughput

0.606

High

1193562

KRA98
Keratin-associated protein 9-8

2

6

High-throughput

0.606

High

1193563

KRA42
Keratin-associated protein 4-2

2

6

High-throughput

0.606

High

1193569

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1193567

TXNIP
Thioredoxin-interacting protein

2

0

High-throughput

0.602

High

132730

BMAL1
Basic helix-loop-helix ARNT-like protein 1

2

18

Small-scale

0.586

High

192927

CLOCK
Circadian locomoter output cycles protein kaput

2

15

Small-scale

0.586

High

1193576

FXL21
Putative F-box/LRR-repeat protein 21

2

7

Small-scale

0.586

High

172883

XPO1
Exportin-1

2

4

High-throughput

0.584

High

1157742

DDB1
DNA damage-binding protein 1

2

2

Small-scale

0.584

High

1193554

FBXW7
F-box/WD repeat-containing protein 7

2

3

Small-scale

0.584

High

74341

ZBT42
Zinc finger and BTB domain-containing protein 42

2

0

High-throughput

0.580

High

186554

TRI18
E3 ubiquitin-protein ligase Midline-1

2

0

High-throughput

0.580

High

339080

NADK
NAD kinase

2

0

High-throughput

0.580

High

1186824

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.580

High

1193534

K1C40
Keratin, type I cytoskeletal 40

2

0

High-throughput

0.580

High

1193540

KRA52
Keratin-associated protein 5-2

2

0

High-throughput

0.580

High

1193548

KLHL6
Kelch-like protein 6

2

0

High-throughput

0.580

High

1193566

SDCB2
Syntenin-2

2

0

High-throughput

0.580

High

995069

CSK2B
Casein kinase II subunit beta

1

3

Small-scale

0.561

High

503703

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

1

High-throughput

0.553

High

1180090

VWC2
Brorin

2

1

High-throughput

0.553

High

1154371

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.541

High

1112524

CUL1
Cullin-1

1

2

Small-scale

0.536

High

927333

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

517014

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.515

High

705374

GRN
Progranulin

1

1

High-throughput

0.515

High

659494

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

1032329

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

1193571

SRTD4
SERTA domain-containing protein 4

1

0

High-throughput

0.513

High

1186733

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

385804

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.481

High

718129

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

4

High-throughput

0.481

High

1131665

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

High-throughput

0.481

High

1155429

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.481

High

1158049

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

3

High-throughput

0.481

High

1193538

KRA53
Keratin-associated protein 5-3

1

8

High-throughput

0.481

High

1193542

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.481

High

1193557

TTC1
Tetratricopeptide repeat protein 1

1

7

Small-scale

0.481

High

1193559

NPAS2
Neuronal PAS domain-containing protein 2

1

16

High-throughput

0.481

High

1193564

BHE41
Class E basic helix-loop-helix protein 41

1

10

High-throughput

0.481

High

127979

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.479

High

141513

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

High-throughput

0.479

High

172121

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

5

High-throughput

0.479

High

193113

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

6

High-throughput

0.479

High

207557

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.479

High

209575

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.479

High

210963

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

287940

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.479

High

289565

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

8

High-throughput

0.479

High

325868

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

High-throughput

0.479

High

334022

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.479

High

460548

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

461552

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

468444

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

532631

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

537269

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

547620

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

558181

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

565924

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

576777

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

586727

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

610351

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

620397

NUCL
Nucleolin

1

4

High-throughput

0.479

High

637546

FLNA
Filamin-A

1

1

High-throughput

0.479

High

646856

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

658211

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

691065

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

693773

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

698296

MAP4
Microtubule-associated protein 4

1

1

High-throughput

0.479

High

724091

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.479

High

755727

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.479

High

755945

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.479

High

756226

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.479

High

778693

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

821382

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

834324

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.479

High

834462

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

841765

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

846327

MATR3
Matrin-3

1

3

High-throughput

0.479

High

851335

PRS6B
26S proteasome regulatory subunit 6B

1

5

High-throughput

0.479

High

875988

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.479

High

881198

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

882698

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

890498

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.479

High

899064

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

899412

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.479

High

907461

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

910538

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.479

High

911260

IMA5
Importin subunit alpha-5

1

4

High-throughput

0.479

High

920819

ACLY
ATP-citrate synthase

1

1

High-throughput

0.479

High

934088

XPO2
Exportin-2

1

4

High-throughput

0.479

High

937269

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

940257

SYMC
Methionine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

953904

IF4A1
Eukaryotic initiation factor 4A-I

1

6

High-throughput

0.479

High

965708

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

968939

PRS8
26S proteasome regulatory subunit 8

1

6

High-throughput

0.479

High

971589

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

972433

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

977508

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.479

High

981519

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

991038

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.479

High

996189

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

997756

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.479

High

1007044

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.479

High

1008180

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

1051764

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.479

High

1058442

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

1059855

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

High-throughput

0.479

High

1098004

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

1124259

IF4A2
Eukaryotic initiation factor 4A-II

1

9

High-throughput

0.479

High

1138276

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1144357

NONO
Non-POU domain-containing octamer-binding protein

1

4

High-throughput

0.479

High

1146690

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

1193533

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.479

High

1193541

DET1
DET1 homolog

1

1

Small-scale

0.479

High

1193543

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1193544

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.479

High

1193549

GCN1
Stalled ribosome sensor GCN1

1

5

High-throughput

0.479

High

1193550

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

High-throughput

0.479

High

1193551

FUBP2
Far upstream element-binding protein 2

1

4

High-throughput

0.479

High

1193552

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.479

High

1193553

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.479

High

1193556

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

1193558

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.479

High

1193560

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1193570

SMC4
Structural maintenance of chromosomes protein 4

1

1

High-throughput

0.479

High

1193573

DDX20
Probable ATP-dependent RNA helicase DDX20

1

9

High-throughput

0.479

High

1193575

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

1193579

DICER
Endoribonuclease Dicer

1

4

High-throughput

0.479

High

1193580

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1193581

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.479

High

529

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.460

High

799179

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.460

High

168260

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

175065

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

229024

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

347068

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

417469

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

475372

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.458

High

483581

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.458

High

624558

SPEE
Spermidine synthase

1

0

High-throughput

0.458

High

837645

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

855877

CRKL
Crk-like protein

1

0

High-throughput

0.458

High

921913

COPA
Coatomer subunit alpha

1

0

High-throughput

0.458

High

934696

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

978976

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1123921

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1193535

NXN
Nucleoredoxin

1

0

High-throughput

0.458

High

1193546

GEMI5
Gem-associated protein 5

1

0

High-throughput

0.458

High

1193568

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.458

High

1193574

APC7
Anaphase-promoting complex subunit 7

1

0

High-throughput

0.458

High

1193572

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

420561

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

565629

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.437

High

70242

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

771071

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

High-throughput

0.282

High

1193531

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

1193532

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1193561

DDA1
DET1- and DDB1-associated protein 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025