HitPredict

Interactor 1: RHG32 (A7KAX9)
Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
Gene: ARHGAP32

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2087 Hs			1 822
+	Mm
		546314 RHG32_MOUSE (1-2087): 0: 1404: 87.28		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Hs
		64711 RHG32_HUMAN (1-2087): 0: 1424: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		64640 RHG32_HUMAN (1-2087): 0: 1424: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		64659 RHG32_HUMAN (1-2087): 0: 1424: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		64694 RHG32_HUMAN (1-2087): 0: 1424: 100.00		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		64695 RHG32_HUMAN (1-2087): 0: 1424: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		64625 RHG32_HUMAN (1-2087): 0: 1424: 100.00		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92
+	Hs
		384788 MYO9B_HUMAN (43-823): 2.74e-75: 281: 13.14		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		253302 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		607950 RHG01_HUMAN (188-572): 1.29e-69: 243: 18.09		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		384998 RHG17_HUMAN (189-1018): 1.7e-69: 255: 14.81		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		385580 RHG35_HUMAN (9-584): 3.79e-67: 254: 16.47		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		253307 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		508041 RHG29_HUMAN (134-911): 5.44e-66: 249: 11.78		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		507972 ABR_HUMAN (350-569): 2.79e-66: 245: 32.89		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		507962 RHG01_HUMAN (188-572): 1.29e-69: 243: 18.09		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Rn
		88969 D4A9G6_RAT (67-1276): 6.25e-110: 386: 31.39		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		253341 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		435622 RHG01_HUMAN (188-572): 1.29e-69: 243: 18.09		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411366 RHG01_HUMAN (188-572): 1.29e-69: 243: 18.09		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38