Protein: HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5 (Cat eye syndrome critical region protein 5)

Gene: HDHD5
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9BXW7

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0046474 - glycerophospholipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532926

CH60
60 kDa heat shock protein, mitochondrial

4

0

High-throughput

0.661

High

1142761

PDK3
[Pyruvate dehydrogenase

3

0

High-throughput

0.638

High

1417437

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

1

High-throughput

0.618

High

275371

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

348709

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.513

High

869227

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

1123411

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1160441

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1242622

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1350876

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1389190

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1417439

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1417440

EMRE
Essential MCU regulator, mitochondrial

1

0

High-throughput

0.513

High

1417448

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1417449

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1417450

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1417454

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1417456

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

664083

PRTN3
Myeloblastin

1

2

High-throughput

0.489

High

1417455

KLK5
Kallikrein-5

1

1

High-throughput

0.489

High

242811

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

282068

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

1083732

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

221657

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.458

High

471226

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

880112

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

1033770

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1092639

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1162537

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1386512

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

1

0

Small-scale

0.458

High

1417441

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1417453

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1417457

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.458

High

1255386

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

653550

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1209615

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1417460

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

628458

KLK2
Kallikrein-2

1

1

High-throughput

0.407

High

634800

GRAH
Granzyme H

1

2

High-throughput

0.407

High

1382376

SPSB4
SPRY domain-containing SOCS box protein 4

1

1

High-throughput

0.407

High

260946

RAMP3
Receptor activity-modifying protein 3

2

0

High-throughput

0.313

High

127725

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.279

Low

377898

TNFB
Lymphotoxin-alpha

1

0

High-throughput

0.279

Low

571632

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.279

Low

749385

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

841581

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.279

Low

1295033

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

1349108

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1402409

RSLAB
Ras-like protein family member 10B

1

0

High-throughput

0.279

Low

1417438

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

1417447

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1417452

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1417458

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

407818

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.251

Low

125603

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

315976

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

331285

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

589602

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

607074

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

696415

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769084

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831368

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

971028

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1067684

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.249

Low

1100335

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1121326

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

1137144

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.249

Low

1138597

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

1161800

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.249

Low

1178358

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1208408

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

0

Small-scale

0.249

Low

1352188

SSH3
Protein phosphatase Slingshot homolog 3

1

0

High-throughput

0.249

Low

1380139

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.249

Low

1397399

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1417442

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1417444

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1417445

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.249

Low

273922

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.232

Low

295630

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

320499

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.232

Low

333173

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

0

High-throughput

0.232

Low

346777

CER1
Cerberus

1

0

High-throughput

0.232

Low

388799

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.232

Low

457669

TBB5
Tubulin beta chain

1

0

High-throughput

0.232

Low

538805

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.232

Low

955896

GMFB
Glia maturation factor beta

1

0

High-throughput

0.232

Low

1185897

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low

1227393

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1356704

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

High-throughput

0.232

Low

1384593

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.232

Low

1417443

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.232

Low

1417446

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.232

Low

1417451

PCDGG
Protocadherin gamma-B4

1

0

High-throughput

0.232

Low

1417459

NPTN
Neuroplastin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025