HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	14970201, 29089450, 33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 986
+	Hs
		909883 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Mm
		926797 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG2_MOUSE (1-986): 0: 716: 88.55
+	Hs
		909491 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Hs
		646842 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Mm
		910228 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Mm
		926776 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Hs
		909803 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Hs
		647099 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Mm
		926817 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHGI_MOUSE (1-982): 5.64e-125: 414: 28.54
+	Hs
		909921 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Hs
		909551 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Hs
		647196 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Mm
		926851 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG6_MOUSE (15-797): 3.96e-98: 328: 11.14
+	Mm
		926883 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00
+	Hs
		909501 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Mm
		926773 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		RGRF2_MOUSE (44-801): 1.81e-89: 312: 12.66
+	Hs
		646851 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Hs
		910068 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHG4_HUMAN (72-648): 7.86e-86: 292: 12.85
+	Hs
		909662 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06
+	Hs
		646986 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06