Protein: RPA2
DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2)

Gene: RPA2, RPA135
Organism: Saccharomyces cerevisiae S288C
Interactions: 213
UniProt ID: P22138

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005736 - RNA polymerase I complex
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534215

RPA1
DNA-directed RNA polymerase I subunit RPA190

17

20

Small-scale

0.986

High

459019

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

10

17

Small-scale

0.976

High

644891

RPA12
DNA-directed RNA polymerase I subunit RPA12

9

13

Small-scale

0.972

High

644972

RPA49
DNA-directed RNA polymerase I subunit RPA49

9

5

Small-scale

0.966

High

644947

RPA43
DNA-directed RNA polymerase I subunit RPA43

9

1

Small-scale

0.965

High

644880

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

6

9

Small-scale

0.949

High

644936

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

6

Small-scale

0.891

High

644867

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

9

Small-scale

0.891

High

644949

RPA34
DNA-directed RNA polymerase I subunit RPA34

6

0

High-throughput

0.884

High

644879

SPT5
Transcription elongation factor SPT5

3

4

Small-scale

0.853

High

644959

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

1

High-throughput

0.789

High

632227

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

8

High-throughput

0.776

High

644908

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

2

2

Small-scale

0.776

High

381402

H2B2
Histone H2B.2

2

4

High-throughput

0.759

High

594187

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

17

Small-scale

0.754

High

644866

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

10

High-throughput

0.754

High

644868

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

10

High-throughput

0.754

High

644955

RPA14
DNA-directed RNA polymerase I subunit RPA14

2

0

High-throughput

0.736

High

632124

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

6

10

High-throughput

0.735

High

523070

HSP71
Heat shock protein SSA1

6

6

High-throughput

0.722

High

644897

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

2

High-throughput

0.665

High

381873

H4
Histone H4

3

3

High-throughput

0.662

High

644989

RRP5
rRNA biogenesis protein RRP5

2

2

Small-scale

0.659

High

645019

IF6
Eukaryotic translation initiation factor 6

3

1

High-throughput

0.650

High

644971

CDC14
Tyrosine-protein phosphatase CDC14

3

4

Small-scale

0.640

High

644950

NET1
Nucleolar protein NET1

4

2

Small-scale

0.623

High

644874

RAD51
DNA repair protein RAD51

2

5

High-throughput

0.621

High

419598

H2A2
Histone H2A.2

1

3

High-throughput

0.618

High

434830

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

444421

DED1
ATP-dependent RNA helicase DED1

1

1

High-throughput

0.618

High

644878

NSR1
Nuclear localization sequence-binding protein

1

1

High-throughput

0.618

High

644881

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.618

High

644912

RDH54
DNA repair and recombination protein RDH54

1

3

High-throughput

0.618

High

644968

H3
Histone H3

1

4

High-throughput

0.618

High

644983

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

13

High-throughput

0.618

High

644992

MRD1
Multiple RNA-binding domain-containing protein 1

1

3

High-throughput

0.618

High

525932

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.611

High

543828

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.611

High

632302

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

6

High-throughput

0.611

High

644869

SAN1
Protein SAN1

2

1

Small-scale

0.611

High

645017

RUVB2
RuvB-like protein 2

2

8

High-throughput

0.611

High

644872

SIS1
Protein SIS1

2

3

High-throughput

0.601

High

644905

NDK
Nucleoside diphosphate kinase

2

0

High-throughput

0.595

High

644913

ATR
Serine/threonine-protein kinase MEC1

1

1

Small-scale

0.589

High

644906

DOA1
Protein DOA1

2

4

High-throughput

0.588

High

645000

RIX7
Ribosome biogenesis ATPase RIX7

2

3

High-throughput

0.588

High

644910

NOP4
Nucleolar protein 4

1

0

High-throughput

0.586

High

644982

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.586

High

444739

SIR2
NAD-dependent histone deacetylase SIR2

2

2

Small-scale

0.584

High

644884

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

644938

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.584

High

644945

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

392235

HSP82
ATP-dependent molecular chaperone HSP82

2

4

High-throughput

0.571

High

637168

PWP1
Periodic tryptophan protein 1

2

5

High-throughput

0.571

High

644970

SEN1
Helicase SEN1

2

3

Small-scale

0.571

High

644900

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.559

High

644961

PESC
Pescadillo homolog

2

0

High-throughput

0.559

High

149586

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.553

High

433451

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.553

High

632526

DBP3
ATP-dependent RNA helicase DBP3

1

2

High-throughput

0.553

High

644894

DRS1
ATP-dependent RNA helicase DRS1

1

5

High-throughput

0.553

High

644914

MAK5
ATP-dependent RNA helicase MAK5

1

7

High-throughput

0.553

High

644977

HAS1
ATP-dependent RNA helicase HAS1

1

6

High-throughput

0.553

High

645013

HSP42
Heat shock protein 42

2

2

High-throughput

0.549

High

553580

ERF1
Eukaryotic peptide chain release factor subunit 1

2

2

High-throughput

0.537

High

417025

VDAC1
Non-selective voltage-gated ion channel 1

1

3

High-throughput

0.536

High

574635

KSS1
Mitogen-activated protein kinase KSS1

1

4

High-throughput

0.536

High

644870

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

5

High-throughput

0.536

High

644890

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.536

High

644898

SPT4
Transcription elongation factor SPT4

1

1

Small-scale

0.536

High

644928

FHP
Flavohemoprotein

1

1

High-throughput

0.536

High

644964

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

645015

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.536

High

512260

RS6A
Small ribosomal subunit protein eS6A

2

2

High-throughput

0.533

High

644943

BUD27
Bud site selection protein 27

2

2

Small-scale

0.533

High

645018

NOP58
Nucleolar protein 58

2

3

High-throughput

0.533

High

453421

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.513

High

454399

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

644946

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

644990

RRP45
Exosome complex component RRP45

1

0

High-throughput

0.493

High

364928

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.489

High

368320

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.489

High

386566

TBB
Tubulin beta chain

1

1

High-throughput

0.489

High

531243

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.489

High

575381

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

4

High-throughput

0.489

High

644886

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

6

High-throughput

0.489

High

644889

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.489

High

644917

GID4
GID complex substrate-recognition subunit 4

1

1

High-throughput

0.489

High

644929

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.489

High

644940

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.489

High

644933

LSM5
LSM complex subunit LSM5

1

0

High-throughput

0.486

High

436318

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.479

High

514460

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

547761

NHP6A
Non-histone chromosomal protein 6A

1

5

High-throughput

0.479

High

547850

NHP6B
Non-histone chromosomal protein 6B

1

5

High-throughput

0.479

High

585854

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.479

High

644871

CG23
G2/mitotic-specific cyclin-3

1

1

High-throughput

0.479

High

644877

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

644882

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

644883

PTP2
Tyrosine-protein phosphatase 2

1

1

High-throughput

0.479

High

644885

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

644887

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.479

High

644893

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

644896

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

644899

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

644903

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

644911

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

644915

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.479

High

644918

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.479

High

644921

ECM29
Proteasome component ECM29

1

3

High-throughput

0.479

High

644922

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

644923

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

644924

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

4

High-throughput

0.479

High

644930

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

644932

SNU13
13 kDa ribonucleoprotein-associated protein

1

1

High-throughput

0.479

High

644935

ATAD2
ATPase histone chaperone YTA7

1

6

High-throughput

0.479

High

644937

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

644939

NOP2
25S rRNA

1

1

High-throughput

0.479

High

644942

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

644956

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

644958

MSN5
Protein MSN5

1

4

Small-scale

0.479

High

644960

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.479

High

644965

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.479

High

644967

RL15B
Large ribosomal subunit protein eL15B

1

3

High-throughput

0.479

High

644974

TOF2
Topoisomerase 1-associated factor 2

1

2

High-throughput

0.479

High

644976

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

644978

VHS1
Serine/threonine-protein kinase VHS1

1

1

High-throughput

0.479

High

644980

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.479

High

644981

HMO1
High mobility group protein 1

1

7

High-throughput

0.479

High

644987

POB3
FACT complex subunit POB3

1

3

High-throughput

0.479

High

644988

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.479

High

644991

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

1

Small-scale

0.479

High

644993

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

644994

FKBP4
FK506-binding protein 4

1

4

High-throughput

0.479

High

644995

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

644998

IWR1
RNA polymerase II nuclear localization protein IWR1

1

1

High-throughput

0.479

High

645004

SGO1
Shugoshin

1

2

High-throughput

0.479

High

645009

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

5

High-throughput

0.479

High

645010

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

645011

MAK21
Ribosome biogenesis protein MAK21

1

1

High-throughput

0.479

High

645012

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

645016

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

644985

SPC24
Kinetochore protein SPC24

1

0

Small-scale

0.460

High

149193

FOB1
DNA replication fork-blocking protein FOB1

1

0

High-throughput

0.458

High

644909

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

644916

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

644948

TRM61
tRNA

1

0

High-throughput

0.458

High

644962

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

644963

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

644969

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

644975

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

644979

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

644984

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

645001

NOC3
Nucleolar complex-associated protein 3

1

0

High-throughput

0.458

High

645007

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

645008

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

645021

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

456332

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.445

High

509398

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.445

High

566483

DHAS
Aspartate-semialdehyde dehydrogenase

1

2

High-throughput

0.445

High

597708

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

644892

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

644901

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.445

High

644925

CAJ1
Protein CAJ1

1

4

High-throughput

0.445

High

644931

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.445

High

644934

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

644957

PFD6
Prefoldin subunit 6

1

4

High-throughput

0.445

High

383521

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

409939

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

434321

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.437

High

435777

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

441708

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

454880

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

464551

PBS2
MAP kinase kinase PBS2

1

6

High-throughput

0.437

High

502852

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504041

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512823

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

558585

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

585205

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.437

High

644873

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

644888

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

1

High-throughput

0.437

High

644895

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

644902

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

644919

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

644927

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

644941

KRI1
Protein KRI1

1

1

High-throughput

0.437

High

644951

GPN1
GPN-loop GTPase 1

1

13

Small-scale

0.437

High

644953

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

644954

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

644966

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.437

High

644973

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

644997

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

645002

PSR2
Probable phosphatase PSR2

1

4

High-throughput

0.437

High

645005

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

454077

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.426

High

644926

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

644944

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.426

High

645014

JID1
J domain-containing protein 1

1

0

High-throughput

0.426

High

427138

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

644920

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.407

High

644904

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.313

High

513950

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

644875

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

644876

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

644907

EBP2
rRNA-processing protein EBP2

1

0

High-throughput

0.249

Low

644952

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.249

Low

644986

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.249

Low

644996

BFR2
Protein BFR2

1

0

High-throughput

0.249

Low

644999

NOP6
Nucleolar protein 6

1

0

High-throughput

0.249

Low

645003

BRX1
Ribosome biogenesis protein BRX1

1

0

High-throughput

0.249

Low

645006

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.249

Low

645020

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025