HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 577
+	Hs
		909555 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Mm
		93548 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		DESP_MOUSE (8-574): 5.01e-15: 81: 9.86
+	Hs
		909975 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		909625 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		725130 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		522590 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MYH7_HUMAN (171-563): 8.39e-15: 80.3: 16.29
+	Hs
		647234 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		646898 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Mm
		910250 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		GRDN_MOUSE (94-573): 1.71e-11: 69.5: 9.84
+	Hs
		646944 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		728460 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Mm
		926804 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		MYH10_MOUSE (233-561): 5.58e-13: 74.5: 11.18
+	Hs
		909488 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CGNL1_HUMAN (196-556): 1.23e-10: 66.8: 12.06
+	Hs
		647370 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MYH2_HUMAN (226-567): 1.02e-12: 73.3: 11.82
+	Mm
		926795 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		GRDN_MOUSE (94-573): 1.71e-11: 69.5: 9.84
+	Mm
		926886 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		MY18A_MOUSE (149-549): 2.32e-11: 69.3: 15.44
+	Hs
		646685 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Hs
		646838 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CGNL1_HUMAN (196-556): 1.23e-10: 66.8: 12.06
+	Mm
		926855 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		MYH9_MOUSE (266-576): 6.92e-10: 64.5: 13.51
+	Hs
		646681 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08