Protein: VPS1
Vacuolar protein sorting-associated protein 1

Gene: VPS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 178
UniProt ID: P21576

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000266 - mitochondrial fission
GO:0000329 - fungal-type vacuole membrane
GO:0000407 - phagophore assembly site
GO:0003924 - GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

639098

ATG11
Autophagy-related protein 11

3

1

Small-scale

0.664

High

639092

VAM3
Syntaxin VAM3

3

0

Small-scale

0.651

High

639090

ATG9
Autophagy-related protein 9

3

0

Small-scale

0.633

High

614794

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

2

9

High-throughput

0.621

High

638983

BTAF1
TATA-binding protein-associated factor MOT1

2

5

High-throughput

0.621

High

638988

CHD1
Chromo domain-containing protein 1

2

1

High-throughput

0.621

High

639061

MSH6
DNA mismatch repair protein MSH6

2

1

High-throughput

0.621

High

639018

RV167
Reduced viability upon starvation protein 167

2

20

Small-scale

0.619

High

638967

VPS1
Vacuolar protein sorting-associated protein 1

1

19

Small-scale

0.618

High

639034

ATG36
Autophagy-related protein 36

2

1

Small-scale

0.609

High

639032

TAF1
Transcription initiation factor TFIID subunit 1

2

0

High-throughput

0.595

High

639009

ATG8
Autophagy-related protein 8

2

2

High-throughput

0.584

High

638981

RAD16
DNA repair protein RAD16

2

4

High-throughput

0.567

High

639006

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

2

3

High-throughput

0.567

High

639058

NHP10
Non-histone protein 10

2

4

High-throughput

0.567

High

638985

RPD3
Histone deacetylase RPD3

2

0

High-throughput

0.563

High

639037

RFX1
RFX-like DNA-binding protein RFX1

2

0

High-throughput

0.563

High

639050

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.563

High

638989

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

3

Small-scale

0.552

High

525918

HSP72
Heat shock protein SSA2

2

8

High-throughput

0.552

High

381396

H2B2
Histone H2B.2

2

2

High-throughput

0.537

High

547849

NHP6B
Non-histone chromosomal protein 6B

2

4

High-throughput

0.537

High

574552

YAK1
Dual specificity protein kinase YAK1

1

12

High-throughput

0.536

High

638986

STH1
Nuclear protein STH1/NPS1

1

4

High-throughput

0.536

High

639045

ARP5
Actin-related protein 5

1

4

High-throughput

0.536

High

639052

ABF2
ARS-binding factor 2, mitochondrial

1

4

High-throughput

0.536

High

639057

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.536

High

639062

HMO1
High mobility group protein 1

1

5

High-throughput

0.536

High

639059

INP1
Inheritance of peroxisomes protein 1

1

0

Small-scale

0.527

High

638973

SIS1
Protein SIS1

1

2

High-throughput

0.515

High

454397

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

460945

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.513

High

617766

SNF6
Transcription regulatory protein SNF6

1

0

High-throughput

0.513

High

639042

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

639060

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.513

High

517893

SSBP1
Single-stranded nucleic acid-binding protein

1

3

High-throughput

0.501

High

602315

PHO85
Cyclin-dependent protein kinase PHO85

1

3

Small-scale

0.501

High

639047

ACT
Actin

1

2

Small-scale

0.501

High

639081

RTC1
Restriction of telomere capping protein 1

1

6

High-throughput

0.500

High

380962

H2B1
Histone H2B.1

1

2

High-throughput

0.489

High

639096

ARP7
Actin-related protein 7

1

4

High-throughput

0.489

High

638968

CLH
Clathrin heavy chain

1

2

Small-scale

0.481

High

638994

SNC2
Synaptobrevin homolog 2

1

1

Small-scale

0.481

High

639002

VPS24
Vacuolar protein-sorting-associated protein 24

1

6

Small-scale

0.481

High

639100

YPT6
GTP-binding protein YPT6

1

2

Small-scale

0.481

High

639072

NAT3
N-terminal acetyltransferase B complex catalytic subunit NAT3

1

0

Small-scale

0.480

High

392225

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

509393

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

11

High-throughput

0.479

High

509869

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

5

High-throughput

0.479

High

510191

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.479

High

518204

IF4A
ATP-dependent RNA helicase eIF4A

1

3

High-throughput

0.479

High

536073

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.479

High

578843

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

632776

DBP5
ATP-dependent RNA helicase DBP5

1

2

High-throughput

0.479

High

635020

VPS33
Vacuolar protein sorting-associated protein 33

1

2

Small-scale

0.479

High

638969

VPS15
Serine/threonine-protein kinase VPS15

1

4

High-throughput

0.479

High

638970

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

638971

RFA1
Replication factor A protein 1

1

3

Small-scale

0.479

High

638974

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

638975

CDC48
Cell division control protein 48

1

7

High-throughput

0.479

High

638980

XPO1
Exportin-1

1

4

High-throughput

0.479

High

638982

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

638990

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

4

High-throughput

0.479

High

638992

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

638995

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

639001

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.479

High

639003

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

639015

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

639019

IMB4
Importin subunit beta-4

1

4

High-throughput

0.479

High

639023

ATAD2
ATPase histone chaperone YTA7

1

8

High-throughput

0.479

High

639025

SEC24
Protein transport protein SEC24

1

1

High-throughput

0.479

High

639027

MVP1
Sorting nexin MVP1

1

14

Small-scale

0.479

High

639029

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

639031

ATG18
Autophagy-related protein 18

1

2

High-throughput

0.479

High

639039

ATG1
Serine/threonine-protein kinase ATG1

1

4

High-throughput

0.479

High

639040

CDH1
APC/C activator protein CDH1

1

5

Small-scale

0.479

High

639043

ATG2
Autophagy-related protein 2

1

1

High-throughput

0.479

High

639044

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

639046

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

639049

NUM1
Nuclear migration protein NUM1

1

5

High-throughput

0.479

High

639053

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.479

High

639063

SXM1
Importin beta SMX1

1

3

High-throughput

0.479

High

639064

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

639069

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

639070

IMB1
Importin subunit beta-1

1

3

High-throughput

0.479

High

639087

AP3D
AP-3 complex subunit delta

1

9

High-throughput

0.479

High

639091

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

639093

TPO4
Polyamine transporter 4

1

1

High-throughput

0.479

High

639004

VPS51
Vacuolar protein sorting-associated protein 51

1

0

Small-scale

0.460

High

639065

VTI1
t-SNARE VTI1

1

0

Small-scale

0.460

High

639077

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

Small-scale

0.460

High

639079

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

Small-scale

0.460

High

639097

SNF8
Vacuolar-sorting protein SNF8

1

0

Small-scale

0.460

High

149582

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

401886

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

409936

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

434824

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

441703

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

454875

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

512256

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

512819

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

558582

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

576935

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.458

High

638972

VPS34
Phosphatidylinositol 3-kinase VPS34

1

0

High-throughput

0.458

High

638977

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

638993

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

638996

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

639000

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

639005

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

639010

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

639011

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.458

High

639013

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

639014

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

639017

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

639021

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

639026

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

639028

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

639035

ATG27
Autophagy-related protein 27

1

0

High-throughput

0.458

High

639036

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

639051

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

639054

IMA1
Importin subunit alpha

1

0

High-throughput

0.458

High

639055

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.458

High

639056

ESP1
Separin

1

0

High-throughput

0.458

High

639073

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.458

High

639075

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.458

High

639078

CSR1
Phosphatidylinositol transfer protein CSR1

1

0

High-throughput

0.458

High

639082

SGO1
Shugoshin

1

0

High-throughput

0.458

High

639083

PEX27
Peroxisomal membrane protein PEX27

1

0

Small-scale

0.458

High

639084

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

639085

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

639088

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

639089

ATG29
Autophagy-related protein 29

1

0

High-throughput

0.458

High

394237

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

486028

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.445

High

523053

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

543810

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

638979

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.445

High

638997

MSN2
Zinc finger protein MSN2

1

3

High-throughput

0.445

High

638998

GCN1
eIF-2-alpha kinase activator GCN1

1

2

High-throughput

0.445

High

638999

SPT7
SAGA complex subunit SPT7

1

5

High-throughput

0.445

High

639020

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

1

High-throughput

0.445

High

639022

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

639033

NMD5
Nonsense-mediated mRNA decay protein 5

1

4

High-throughput

0.445

High

639038

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.445

High

419594

H2A2
Histone H2A.2

1

3

High-throughput

0.437

High

638978

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

639008

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

639048

H3
Histone H3

1

4

High-throughput

0.437

High

639066

SEC13
Protein transport protein SEC13

1

1

High-throughput

0.437

High

639086

NCBP2
Nuclear cap-binding protein subunit 2

1

2

High-throughput

0.437

High

639095

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

548750

MCM1
Pheromone receptor transcription factor

1

0

High-throughput

0.426

High

638987

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.426

High

639007

SEA4
SEH-associated protein 4

1

0

High-throughput

0.426

High

639012

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.426

High

639016

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

639076

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.426

High

547760

NHP6A
Non-histone chromosomal protein 6A

1

4

High-throughput

0.407

High

638991

PDC2
Protein PDC2

1

1

High-throughput

0.407

High

639067

RCO1
Transcriptional regulatory protein RCO1

1

2

High-throughput

0.407

High

561416

TBP
TATA-box-binding protein

2

0

High-throughput

0.324

High

638776

REB1
DNA-binding protein REB1

2

0

High-throughput

0.324

High

483748

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.279

Low

639030

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.279

Low

639074

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.279

Low

639094

IES3
Ino eighty subunit 3

1

0

High-throughput

0.279

Low

638976

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

638984

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low

639041

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

639071

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

639101

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

570787

ABF1
ARS-binding factor 1

1

0

High-throughput

0.232

Low

639024

DLS1
Protein DLS1

1

0

High-throughput

0.232

Low

639068

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

639080

THP1
Nuclear mRNA export protein THP1

1

0

High-throughput

0.232

Low

639099

NCB2
Negative cofactor 2 complex subunit beta

1

0

High-throughput

0.232

Low

639102

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025