HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: DUS1 (P28562)
Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
Gene: DUSP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 31980649, 11278799, 10617468, 20347885
Identification Methods affinity chromatography technology, two hybrid, enzymatic study, protein kinase assay, phosphatase assay
Interaction Type physical association, direct interaction, phosphorylation reaction, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007049 - cell cycle
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 379
Hs

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Last updated: 15 Jul 2024