HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: ERF (P50548)
ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)
Gene: ERF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 379 Hs			1 548
+	Rn
		88640 MK03_RAT (13-379): 1.37e-155: 444: 97.55		D3ZJW0_RAT (1-548): 2.97e-78: 258: 94.75
+	Hs
		658856 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		ERF_HUMAN (1-548): 2.67e-75: 250: 100.00
+	Rn
		78170 MK03_RAT (13-379): 1.37e-155: 444: 97.55		B5DEX5_RAT (2-129): 4.26e-56: 186: 79.07
+	Mm
		785338 MK03_MOUSE (13-379): 4.55e-155: 443: 97.28		ELK1_MOUSE (26-423): 1.12e-51: 184: 22.38
+	Hs
		647473 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		ELK4_HUMAN (39-421): 3.37e-46: 169: 19.19
+	Mm
		785336 MK01_MOUSE (28-374): 6.16e-154: 439: 87.61		ELK1_MOUSE (26-423): 1.12e-51: 184: 22.38
+	Hs
		647520 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		ETV1_HUMAN (5-155): 1.51e-43: 163: 30.46
+	Hs
		657805 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		ELK4_HUMAN (39-421): 3.37e-46: 169: 19.19
+	Hs
		541984 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		ETS1_HUMAN (14-131): 5.65e-45: 166: 48.31
+	Hs
		658826 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		ETV3_HUMAN (2-491): 2.82e-41: 157: 40.56
+	Hs
		584206 MK03_HUMAN (1-379): 1.99e-160: 456: 100.00		ELK1_HUMAN (26-452): 5.74e-34: 135: 19.68
+	Dm
		772960 ERKA_DROME (10-379): 4.96e-151: 432: 76.28		PNT_DROME (23-134): 6.07e-39: 153: 49.11
+	Hs
		542010 MK07_HUMAN (2-374): 1.72e-139: 418: 47.23		ETS1_HUMAN (14-131): 5.65e-45: 166: 48.31
+	Hs
		840374 MK14_HUMAN (36-377): 1.51e-111: 332: 49.13		ERF_HUMAN (1-548): 2.67e-75: 250: 100.00
+	Hs
		584208 MK01_HUMAN (28-374): 7.3e-154: 439: 87.90		ELK1_HUMAN (26-452): 5.74e-34: 135: 19.68
+	Ce
		106124 MPK1_CAEEL (10-375): 9.85e-143: 414: 72.13		G5EDL0_CAEEL (27-382): 9.92e-37: 143: 22.31
+	Rn
		926487 MK01_RAT (28-374): 6.16e-154: 439: 87.61		SYNJ1_RAT (95-471): 4.17e-17: 87.2: 12.06
+	Dm
		772961 ERKA_DROME (10-379): 4.96e-151: 432: 76.28		POK_DROME (16-140): 9.29e-12: 69.7: 41.41
+	Hs
		542017 MK14_HUMAN (36-377): 1.51e-111: 332: 49.13		ETS1_HUMAN (14-131): 5.65e-45: 166: 48.31
+	Hs
		840437 MK14_HUMAN (36-377): 1.51e-111: 332: 49.13		ETV1_HUMAN (5-155): 1.51e-43: 163: 30.46