HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	29326975
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 1 others more... GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 379 Hs			1 303
+	Rn
		61800 MK03_RAT (13-379): 1.37e-155: 444: 97.55		CHIP_RAT (1-303): 4.82e-68: 216: 97.37
+	At
		1106347 MPK4_ARATH (1-374): 1.05e-152: 436: 47.48		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1259046 MPK16_ARATH (19-377): 1.72e-145: 425: 44.23		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1106458 MPK5_ARATH (1-373): 1.04e-144: 416: 47.34		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1106712 MPK7_ARATH (16-374): 1.13e-139: 403: 44.32		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1106103 MPK2_ARATH (14-374): 3.5e-139: 402: 46.15		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73