HitPredict

Interactor 1: MARK3 (P27448)
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)
Gene: MARK3

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.764

Property	Details
Experiments	25852190, 29089450, 35271311, 32707033, 36736316, 16968750, 26496610, 33961781, 36931259, 16306228, 14676191, 20642453, 28514442, 16959763, 15161933
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification, far western blotting
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0070062 - extracellular exosome GO:1900181 - negative regulation of protein localization to nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 753 Hs			1 245
+	Hs
		647862 MARK3_HUMAN (1-753): 0: 769: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Mm
		926780 MARK3_MOUSE (1-753): 0: 763: 97.08		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Mm
		910231 MARK3_MOUSE (1-753): 0: 763: 97.08		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		646650 MARK3_HUMAN (1-753): 0: 769: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		647835 MARK3_HUMAN (1-753): 0: 769: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Mm
		975157 MARK3_MOUSE (1-753): 0: 763: 97.08		1433B_MOUSE (1-242): 3.77e-128: 364: 87.19
+	Xl
		223344 Q804T2_XENLA (1-753): 0: 723: 88.31		O57468_XENLA (2-241): 8.77e-143: 401: 68.18
+	Hs
		647860 MARK3_HUMAN (1-753): 0: 769: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		647879 MARK3_HUMAN (1-753): 0: 769: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Mm
		905331 MARK3_MOUSE (1-753): 0: 763: 97.08		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Mm
		935481 MARK3_MOUSE (1-753): 0: 763: 97.08		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07
+	Hs
		647836 MARK3_HUMAN (1-753): 0: 769: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Xl
		223345 Q8QGV3_XENLA (1-753): 0: 637: 59.40		O57468_XENLA (2-241): 8.77e-143: 401: 68.18
+	Hs
		927214 MARK2_HUMAN (2-753): 0: 626: 59.90		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909730 MARK2_HUMAN (2-753): 0: 626: 59.90		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		647041 MARK2_HUMAN (2-753): 0: 626: 59.90		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683485 MARK2_HUMAN (2-753): 0: 626: 59.90		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		904766 MARK2_HUMAN (2-753): 0: 626: 59.90		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982193 MARK2_HUMAN (2-753): 0: 626: 59.90		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		684157 MARK2_HUMAN (2-753): 0: 626: 59.90		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97